Protein Alignment CYP3A4 and Cyp313a1

DIOPT Version :10

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_650368.1
• Gene: Cyp313a1 / 41759
• FlyBaseID: FBgn0038236
• Length: 492
• Species: Drosophila melanogaster
• Alignment Length: 484
• Identity: 134/484 - (27%)
• Similarity: 226/484 - (46%)
• Gaps: 63/484 - (13%)

Human    13 LLLAV-SLVLLYLYGTHSHGLFKKLGIPGPTPLPFLG----NILSYHKGFCMFDMECHKKYGKVW 72
            ||||| :|..:|...:.....|..|.||||..||.||    ||::| |....|..:...|||...
  Fly     6 LLLAVGALFWIYFLWSRRRLYFLMLKIPGPIGLPILGSSLENIITY-KRKLSFRTKYLNKYGSTI 69

Human    73 GFYDGQQPVLAITDPDMIKTVLVK-ECY-------SVFTNRRPFGPVGFMKSAISIAEDEEWKRL 129
            ..:.|..|.:...||.:::.:... :|:       :..|:....|.:|        .:|..|...
  Fly    70 LTWMGPVPFIVTRDPKVVEDIFSSPDCHNKSQHIVNAITSCMGNGLLG--------KQDPHWLDR 126

Human   130 RSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGK----PVTLKDVFGAYSMDVITSTSFG 190
            |...:|:|....|.....|......||:..|....:.|:    |..|:     :|..:...|:.|
  Fly   127 RKHFNPSFKQDLLLSFFHIFDAETKVLMNLLDTYVDKGEIDVVPEMLR-----WSFKIAAQTTMG 186

Human   191 VNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILE---VLNICVFPR-EVTNFLRK 251
            ..:     ..|...:|...:..|:.|    :|.:....|:|:::   :..||.:.: ...||.|
  Fly   187 SEV-----KHDEHFKNGSLVESFESL----ISHSTLNILMPLVQNRMISKICGYDKLRADNFSR- 241

Human   252 SVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKA--------LSDLELVAQSIIFIFAGYE 308
             :::|    |::....:|:.|. ..||........::|        ::.:::.::..|.|.|||:
  Fly   242 -IQKM----LDNVVNKKVNPLP-KTDSDPESNIVINRAMELYRKGDITYMDVKSECCIMIAAGYD 300

Human   309 TTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKA--PPTYDTVLQMEYLDMVVNETLRLFPIAM 371
            |::..:...::.||.||:.|:.:.||::.|.|:..  ..||..:.:::||:.|:.|||||.|...
  Fly   301 TSALTVYHALFLLANHPEHQEAVFEELNGVFPDAGHFGITYPDMQKLDYLERVIKETLRLIPAIP 365

Human   372 RLERVCKKDVEI-NGMFIPKGVVVMIPSYALHRDPKYW-TEPEKFLPERFSKKNKDNIDPYIYTP 434
            ...|..|.||.: ||:.||||||:.|..:..||:|:.| .:.:.|.|:.|..:|.:...||.|.|
  Fly   366 ITARETKNDVRLSNGVLIPKGVVIGIDMFHTHRNPEVWGPDADNFNPDNFLAENMEQKHPYAYIP 430

Human   435 FGSGPRNCIGMRFALMNMKLALIRVLQNF 463
            |..|.|||||.::|:|:.|.||.|:|:|:
  Fly   431 FARGKRNCIGSKYAMMSSKFALCRILRNY 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	CYP3A	67..492	CDD:410743	112/425 (26%)
Cyp313a1	NP_650368.1	CYP313-like	66..487	CDD:410680	110/423 (26%)