DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP3A4 and Cyp6d5

DIOPT Version :9

Sequence 1:	NP_059488.2	Gene:	CYP3A4 / 1576	HGNCID:	2637	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_650327.1	Gene:	Cyp6d5 / 41706	FlyBaseID:	FBgn0038194	Length:	508	Species:	Drosophila melanogaster

Alignment Length:	512	Identity:	163/512 - (31%)
Similarity:	261/512 - (50%)	Gaps:	57/512 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    13 LLLAVSLVLLYLYGTHSHGLFKKLGIPGP-TPLPFLGNILSYHKGFCMFDMECHKKYGK----VW 72
            |:.||:|:.:||..|.|:  :.:.|.|.. ..:|| |.:.|..||...|.|..:..|..    |.
  Fly     7 LIAAVTLLYVYLKWTFSY--WDRKGFPSTGVSIPF-GALESVTKGKRSFGMAIYDMYKSTKEPVI 68

Human    73 GFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPF-----GPVGFMKSAISIAEDEEWKRLRSL 132
            |.|...:|.|.:.|..:...||||: ::.|.:|..:     .|   |.:::...|...|:.||:.
  Fly    69 GLYLTLRPALLVRDAQLAHDVLVKD-FASFHDRGVYVDEKNDP---MSASLFQMEGASWRALRNK 129

Human   133 LSPTFTSGKLKEMVPIIAQYGDVLVRNLRRE--AETGKPVTLKDVFGAYSMDVITSTSFGVNIDS 195
            |:|:|||||||.|.......||.||.::|::  |...|.:.||.:...|::|:|.:|.||:::||
  Fly   130 LTPSFTSGKLKAMFETSDSVGDKLVDSIRKQLPANGAKELELKKLMATYAIDIIATTIFGLDVDS 194

Human   196 LNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV-FPREVTNFLRKSVKRMKES 259
            ..:|.:.|...:||:.|.:..|   :......||.|.||...:.: :.:|.|..:|:...|..:.
  Fly   195 FADPNNEFQIISKKVNRNNIED---IIRGTSSFLYPGLEKFFVKIGWKQEATERMRELSNRTVDL 256

Human   260 RLEDTQKHRVDFLQLMIDSQN-----------SKETESH--KALSDLELVAQSIIFIFAGYETTS 311
            | |.....|.|.|||::..:|           |.|:..:  |::|...:..|..:|..||||||:
  Fly   257 R-EQNNIVRKDLLQLLLQLRNQGKINTDDNIWSAESTKNGVKSMSKDLIAGQLFLFYVAGYETTA 320

Human   312 SVLSFIMYELATHPDVQQKLQEEI-DAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLER 375
            |..||.:|||..:|:|.:|.:|:: .|:..:....|||.:..|:||:..:.||.|.:|....|.|
  Fly   321 STTSFTLYELTQNPEVMEKAKEDVRSAIEKHGGKLTYDAISDMKYLEACILETARKYPALPLLNR 385

Human   376 VCKKDVEI--NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSG 438
            :|.||..:  :.:.|.||..::|....:|||.:|:.:|..:.|||:.:..||.... .|.|||.|
  Fly   386 ICTKDYPVPDSKLVIQKGTPIIISLIGMHRDEEYFPDPLAYKPERYLENGKDYTQA-AYLPFGEG 449

Human   439 PRNCIGMRFALMNMKLALIRVLQNFSFKPCKE----------------TQIPLKLSL 479
            ||.|||.|...:|:|:|:.:||.||..:..||                :.:|::|||
  Fly   450 PRMCIGARMGKVNVKIAIAKVLSNFDLEIRKEKCEIEFGVYGIPLMPKSGVPVRLSL 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	154/486 (32%)
Cyp6d5	NP_650327.1	p450	66..478	CDD:278495	138/420 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920