DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP3A4 and Cyp9f2

DIOPT Version :9

Sequence 1:	NP_059488.2	Gene:	CYP3A4 / 1576	HGNCID:	2637	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_650189.1	Gene:	Cyp9f2 / 41520	FlyBaseID:	FBgn0038037	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	179/524 - (34%)
Similarity:	292/524 - (55%)	Gaps:	47/524 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    10 ETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILS-YHKGFCMFDMEC--HKKYG-- 69
            |.:.|.|::..|.|.:.:.::..||..||....|:.:.||:.. :.:...|||:.|  :.|.|
  Fly     4 EFFALFAIAAALFYRWASANNDFFKDRGIAYEKPVLYFGNMAGMFLRKRAMFDIVCDLYTKGGSK 68

Human    70 KVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRR----------PFGPVGFMKSAISIAEDE 124
            |.:|.::.:||:|.:.|||:||.:.:|: :..|.|.|          |........|::....|.
  Fly    69 KFFGIFEQRQPLLMVRDPDLIKQITIKD-FDHFINHRNVFATSSDDDPHDMSNLFGSSLFSMRDA 132

Human   125 EWKRLRSLLSPTFTSGKLKEMVPIIAQYG----DVLVRNLRREAETGKPVTLKDVFGAYSMDVIT 185
            .||.:||.|||.||..|:::|..::.|..    |.|.::..|..|  ..:.:||....::.|||.
  Fly   133 RWKDMRSTLSPAFTGSKMRQMFQLMNQVAKEAVDCLKQDDSRVQE--NELDMKDYCTRFTNDVIA 195

Human   186 STSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTN-FL 249
            ||:||:.::|..:.::.|.:..|||..|.||..  :...:|..|..:.::|.:.:|.|:.|. |:
  Fly   196 STAFGLQVNSFKDRENTFYQMGKKLTTFTFLQS--MKFMLFFALKGLNKILKVELFDRKSTQYFV 258

Human   250 RKSVKRMKESRLEDTQKH---RVDFLQLMIDSQNSKETESHKA-----LSDLELVAQSIIFIFAG 306
            |..:..||.     .|:|   |.|.:.::::::...:||..||     .||.::|||..:|.|||
  Fly   259 RLVLDAMKY-----RQEHNIVRPDMINMLMEARGIIQTEKTKASAVREWSDRDIVAQCFVFFFAG 318

Human   307 YETTSSVLSFIMYELATHPDVQQKLQEEIDAV---LPNKAPPTYDTVLQMEYLDMVVNETLRLFP 368
            :||::.::.|..:||..:.||||:|.||:..|   |..| ..||:.::.|:|||.||||.||.:|
  Fly   319 FETSAVLMCFTAHELMENQDVQQRLYEEVQQVDQDLEGK-ELTYEAIMGMKYLDQVVNEVLRKWP 382

Human   369 IAMRLERVCKKDV--EING--MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDP 429
            .|:.::|.|.||:  :::|  :.:.||.|:.:|:...||||||:..|.||.|||||.:||::|.|
  Fly   383 AAIAVDRECNKDITFDVDGQKVEVKKGDVIWLPTCGFHRDPKYFENPMKFDPERFSDENKESIQP 447

Human   430 YIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGL-LQPEKPVVLKV 493
            :.|.|||.|.|||||.||||:..|..:..:|:::.|.|.|::.|||:|...|. |.|:....:|:
  Fly   448 FTYFPFGLGQRNCIGSRFALLEAKAVIYYLLKDYRFAPAKKSCIPLELITSGFQLSPKGGFWIKL 512

Human   494 ESRD 497
            ..|:
  Fly   513 VQRN 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	168/489 (34%)
Cyp9f2	NP_650189.1	p450	36..510	CDD:278495	168/484 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1946
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H111391
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2940
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8623
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2429
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.900