Protein Alignment CYP3A4 and Cyp313a3

DIOPT Version :10

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_650170.2
• Gene: Cyp313a3 / 41488
• FlyBaseID: FBgn0038007
• Length: 492
• Species: Drosophila melanogaster
• Alignment Length: 496
• Identity: 144/496 - (29%)
• Similarity: 220/496 - (44%)
• Gaps: 71/496 - (14%)

Human     9 METW-LLLAVSLVL-LY-------LYGTHSHGLFKKLGIPGPTPLPFLG----NILSYHKGFCMF 60
            |:|: |||||.:.. :|       ||..|    ||   ||||..||.||    .:::|.:
  Fly     1 MDTFQLLLAVGVCFWIYFLWSRRRLYMMH----FK---IPGPMGLPILGIAFEYLITYKR----- 53

Human    61 DMECHKKYGKVWG----FYDGQQPVLAITDPDMIKTV-LVKECY---SVFTNRRPFGPVGFMK-S 116
            .|....||..::|    .:.|..|.:...||.:.:.: |..||.   |:|:.     ||.... .
  Fly    54 KMSIRTKYMDIYGSTCLVWVGPTPFVITRDPKIAEEIFLSPECLNRSSIFSK-----PVNSCTGD 113

Human   117 AISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSM 181
            .:...|..:|...|..|:|.|....|...:||.......||..|......|:.....|:. .:|.
  Fly   114 GLLSLEASKWVDRRKNLNPAFKQNVLLSFLPIFNSEAKTLVAFLDSLVGQGEKKVRDDIV-RWSF 177

Human   182 DVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIP-----ILEVLNICVF 241
            .:.|.|:.|.::     .:|...:|...|..::    .|:.|.|...|:|     |...|.
  Fly   178 RIATQTTVGTDV-----KKDASFKNDSVLKSYE----TFMKIIVMNVLLPFTHNKIFSTLG---- 229

Human   242 PREVTNFLRKS-VKRMKESRLEDTQKHRVDF-LQLMIDSQNSKETESHK--ALSDLELVAQSIIF 302
            ..|....|.|| |.:|..:.::.....:.:. .|..|.|..:|..|.|:  .:|..|:.::...|
  Fly   230 GFETQKALAKSNVNKMIGTIVDKKLMTKPESGSQPEITSVINKAIELHRNGEMSREEVQSECCSF 294

Human   303 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLP--NKAPPTYDTVLQMEYLDMVVNETLR 365
            :.|.:|||...:...:..||..|:.|..:.:|:..:.|  .....|||.:.:|.:|:.|||||||
  Fly   295 VVAAFETTGDTVYHALILLAMFPEHQDTVYQELKELFPVAGDFEVTYDDLQRMVFLERVVNETLR 359

Human   366 LFPIAMRLERVCKKDVEI-NGMFIPKGVVVMIPSYALHRDPKYW-TEPEKFLPERFSKKNKDNID 428
            |.|......|...:|..: :|:.|||||.:.|..:|.||:..:| |:|..|.|:.|...|..:..
  Fly   360 LIPSVPFTPRETIRDFRLSSGVVIPKGVGIGIDIFATHRNRDHWGTDPSSFNPDHFLPDNVRDRH 424

Human   429 PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCK 469
            ||.|.||..|.|||||.::.||:.||||.::|:|     ||
  Fly   425 PYAYIPFSKGRRNCIGWKYGLMSSKLALSKILRN-----CK 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	CYP3A	67..492	CDD:410743	121/425 (28%)
Cyp313a3	NP_650170.2	CYP313-like	66..487	CDD:410680	119/419 (28%)