Protein Alignment CYP3A4 and Cyp313a2

DIOPT Version :10

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_650169.3
• Gene: Cyp313a2 / 41487
• FlyBaseID: FBgn0038006
• Length: 493
• Species: Drosophila melanogaster
• Alignment Length: 489
• Identity: 132/489 - (26%)
• Similarity: 215/489 - (43%)
• Gaps: 55/489 - (11%)

Human    13 LLLAVSLVLLYLYGTHSHGLFK-KLGIPGPTPLPFLGNILSY---HKGFCMFDMECHKKYGKVWG 73
            ||:|.||:|...:......|:. .:.:||...||.|||.:.|   .:|..........|:|..:.
  Fly     6 LLIAASLILWIRFLWSRRKLYMLMMQLPGRMGLPLLGNSVRYLIISRGRMSSRTTYMDKHGSTYM 70

Human    74 FYDGQQPVLAITDPDMIKTVLVKE-CY---SVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLS 134
            .:.|..|::...||.:.:.||... |.   |..||.....    |...:...:..:|...|..::
  Fly    71 AWIGTTPIVITRDPKIAEKVLTSPFCINRSSQTTNALALS----MGYGLLTLQGSKWMARRKHMN 131

Human   135 PTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNI---DSL 196
            |.|....|...:||.....|:||.........|:...|.|:. .:|..:.|.|:.|.::   |:.
  Fly   132 PAFKHSVLLSFLPIFNAETDLLVSVFDSFVGQGEKDVLSDLI-RWSFAIATQTTLGTDVTKDDNF 195

Human   197 NNPQDPFVENTKKLLRFDFLD---PFFLSITVFP-FLIPILEVLNICVFPREVTNFLRKSVKRMK 257
            .|  |..::..:.:||...::   ||..:..|.. |.:..|...:.....:.:.|.|.|.:....
  Fly   196 EN--DAILKTYQSMLRLTIINIFVPFVQNKIVSKLFGLEWLRRRDASAINKMINNILDKKLNSNP 258

Human   258 ESRLEDTQK---HRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMY 319
            |:..|...|   ||.  ::|..:.:          :|.:||.|:....:.|.:||::..:.:.:.
  Fly   259 ENYCESELKTVIHRA--IELFRNDE----------MSLMELGAECSSMVLAAFETSAHTVYYALV 311

Human   320 ELATHPDVQQKLQEEIDAVLP--NKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVE 382
            .||..|:.|:.:..||....|  .....|:..:.|:.|||.|:||||||.|......|...:|:.
  Fly   312 LLAMFPEHQEMVFNEIKEHFPLAKGIEVTHTDLQQLVYLDRVLNETLRLMPSVPFSSRETLEDLR 376

Human   383 I-NGMFIPKGVVVMIPSYALHRDPKYW------TEPEKFLPERFSKKNKDNIDPYIYTPFGSGPR 440
            : ||:.||||:.:.|..:...|:..||      ..||.||||:...::     ||.:.||..|.|
  Fly   377 LSNGVVIPKGMTISIDIFNTQRNTDYWGSEAAQFNPENFLPEKIHDRH-----PYAFIPFSKGKR 436

Human   441 NCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474
            ||||.|:.||:.||||:::|:|:..|    |..|
  Fly   437 NCIGWRYGLMSSKLALVKILRNYKLK----TSFP 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	CYP3A	67..492	CDD:410743	116/431 (27%)
Cyp313a2	NP_650169.3	CYP313-like	66..487	CDD:410680	115/429 (27%)