Protein Alignment CYP3A4 and Cyp312a1

DIOPT Version :10

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_649030.1
• Gene: Cyp312a1 / 40005
• FlyBaseID: FBgn0036778
• Length: 510
• Species: Drosophila melanogaster
• Alignment Length: 534
• Identity: 136/534 - (25%)
• Similarity: 246/534 - (46%)
• Gaps: 81/534 - (15%)

Human    13 LLLAVSLVLLYLYGTHSH--GLFKKLGIPGPTPLPFLG--NILS-------YHKGFCMFDMECHK 66
            ||||:||.|||::...|.  .|..|.  |.|..|||:|  :||:       ..:...|.:...|.
  Fly     9 LLLALSLYLLYVFERQSRIDRLTHKW--PAPPALPFIGHLHILAKLVGPHPLRRATEMINEHLHD 71

Human    67 KYGKVWGFYDGQQPVLAITDPDMIKTV-----LVKEC--YSVFTNRRPFGPVGFMKSAISIAEDE 124
            ...|:|   .|.:..|...:|..|:.:     |:::.  |.||.|        ::...:..:..|
  Fly    72 HRAKLW---MGTKLYLVDCNPKDIQALCSAQQLLQKTNDYRVFEN--------WLCEGLFTSGFE 125

Human   125 EWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSF 189
            :|...|.::.|.|....:|:.|.:..:...:|:.|:.:.||:|..:....:...:::|.|..|:.
  Fly   126 KWSHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGDQIDFLQLISCFTLDTICETAL 190

Human   190 GVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVK 254
            ||::.|.::.:..:::..|.:|                 :|....:.||  |.|....|.|.|..
  Fly   191 GVSVGSQSSAKSEYLDAVKSIL-----------------VIIDKRLKNI--FYRNSFIFKRTSHY 236

Human   255 RMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLEL--VAQSIIF--------------- 302
            :.::..::.........:|..||..|......:...||.||  |.:::.|
  Fly   237 KREQELIKTLHGFTEGIIQKRIDEINQDAENRNYQSSDAELDGVKRTLCFLDTLLLSKGPDGKPL 301

Human   303 ------------IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPP-TYDTVLQM 353
                        ||.|::.|::.|:|.||.:..||:.||:.:||:.:|. .:|:.| :.:.|.|:
  Fly   302 TVKDIREEVDTIIFGGFDLTATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQVRQL 366

Human   354 EYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPER 418
            |:|:..:.||||::|......|....:..||..|||||..|:|....:.|...::.:|..|.|:|
  Fly   367 EFLEACIKETLRMYPSGPLTARKATANCTINDFFIPKGSDVIISPIYMGRCKDFFPDPMVFKPDR 431

Human   419 FSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLL 483
            ::...:..|:...:.||.:|.|:|:|.|:|::.:|:.|..:|:||.|:|..|.|:.|||:....|
  Fly   432 WAIGAEPKIEATTFIPFMAGARSCMGQRYAMVMLKMVLAHLLRNFLFEPLGERQVKLKLNFVITL 496

Human   484 QPEKPVVLKVESRD 497
            ...:|.:.:.::.|
  Fly   497 HTVEPYLCRAKNLD 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	CYP3A	67..492	CDD:410743	113/462 (24%)
Cyp312a1	NP_649030.1	CYP4	75..504	CDD:410721	113/458 (25%)