Protein Alignment CYP3A4 and Cyp4d8

DIOPT Version :10

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_523961.2
• Gene: Cyp4d8 / 38841
• FlyBaseID: FBgn0015033
• Length: 505
• Species: Drosophila melanogaster
• Alignment Length: 496
• Identity: 129/496 - (26%)
• Similarity: 245/496 - (49%)
• Gaps: 61/496 - (12%)

Human    13 LLLAVSLVLLYLYGTHSHGLFKKLG----------IPGPTPLPFLGN---ILSYH-KGFCMFDME 63
            :||.:.:|||:..|...|     ||          :|||...|.:|.   :|..: |.|.....|
  Fly     1 MLLFLLVVLLFGAGWIIH-----LGQADRRRKVANLPGPICPPLIGAMQLMLRLNPKTFIKVGRE 60

Human    64 CHKKYG---KVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPV--GFMKSAISIAED 123
            ...|:|   :||.|   .:.::...|.::.:.:|..:.:.|   :.|...|  .::.:.:.:::.
  Fly    61 YVLKFGHLQRVWIF---NRLLIMSGDAELNEQLLSSQEHLV---KHPVYKVLGQWLGNGLLLSDG 119

Human   124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTS 188
            :.|.:.|.:::|||....|::.|.:..|..::.|:.|.::| .|....:.....|.::|:|..|:
  Fly   120 KVWHQRRKIITPTFHFSILEQFVEVFDQQSNICVQRLAQKA-NGNTFDVYRSICAAALDIIAETA 183

Human   189 FGVNIDSLNNPQDPFVENTKK---LLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLR 250
            .|..|.:..|...|:.|...:   ||.:.|:..:.....:|....|.|:.....:. |.:..|..
  Fly   184 MGTKIYAQANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQLI-RTMQEFTI 247

Human   251 KSVKRMK------ESRLEDT------QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFI 303
            |.:::.:      :|:|.||      .|.|:..|.:::.|     |...:.|::.|:..:...|:
  Fly   248 KVIEKRRQALEDQQSKLMDTADEDVGSKRRMALLDVLLMS-----TVDGRPLTNDEIREEVDTFM 307

Human   304 FAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL--PNKAPPTYDTVLQMEYLDMVVNETLRL 366
            |.|::||:|.|||.::||:.||:||.|:.|||..||  ....|.:...:.:::|::.|:.|:||:
  Fly   308 FEGHDTTTSALSFCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVIKESLRM 372

Human   367 FP----IAMRLERVCKKDVEING-MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDN 426
            :|    :..:|:...|....::| ..||.|..::|..:.:||.|:.:..|::|:|||  .:|...
  Fly   373 YPPVPIVGRKLQTDFKYTHSVHGDGVIPAGSEIIIGIFGVHRQPETFPNPDEFIPER--HENGSR 435

Human   427 IDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 467
            :.|:...||.:|||||||.:||.:.||:.|.::::.:...|
  Fly   436 VAPFKMIPFSAGPRNCIGQKFAQLEMKMMLAKIVREYELLP 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	CYP3A	67..492	CDD:410743	111/428 (26%)
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	110/426 (26%)