Protein Alignment CYP3A4 and Cyp4d20

DIOPT Version :10

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_647723.2
• Gene: Cyp4d20 / 38311
• FlyBaseID: FBgn0035344
• Length: 510
• Species: Drosophila melanogaster
• Alignment Length: 525
• Identity: 148/525 - (28%)
• Similarity: 260/525 - (49%)
• Gaps: 68/525 - (12%)

Human    12 WLLL---AVSLVLLYLYGTHSHGL--FKKLGIPGPTPLPFLG-NILSYHKG---FCMFDMECHKK 67
            ||.|   |:.|:|.:.:|.....:  |:|..||||..:|.|| .:.:.|.|   ...:..|...|
  Fly     2 WLTLITGALILLLTWDFGRKRQRVLAFEKSAIPGPISIPILGCGLQALHLGAENIIGWVGEKFDK 66

Human    68 YGKVWGFYDGQQPVLAITDPDMIKTVL----VKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKR 128
            |||.:.|:...:.::...|....:|:|    :.|...::...||     |:...:.::...:|..
  Fly    67 YGKTFRFWILGESLIYTKDLQYFETILSSTTLLEKGQLYEYLRP-----FLNDGLLVSTGRKWHA 126

Human   129 LRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNI 193
            .|.:.:..|....|:..|.|:.::..|:|.|||:.|:....|.:.......::||||..:.||.:
  Fly   127 RRKIFTHAFHFKVLEHYVEIMDRHSSVMVDNLRKVADGKTAVDMLKYVSLAALDVITEAAMGVQV 191

Human   194 DSLNNPQDPFVENTKKLL------------RFDFLDPFFLSITVFPFLIPILE---VLNICV--- 240
            ::.|:|..|:::..|.::            |:::|         ||...|:|.   :.:|.|
  Fly   192 NAQNDPDFPYIKALKSVVYIQPDRMFRFSRRYNWL---------FPLAAPLLHRQLLSDIRVMHD 247

Human   241 FPREVTNFLRKSVKRMKES------RLEDTQ---KHRVDFLQLMIDSQNSKETESHKALSDLELV 296
            |..:|.:..|::|:|.|..      .|.|.:   |.::..|.:::.|     :.:::.|||.::.
  Fly   248 FTDKVISERRETVRRAKADGTYRPLSLGDAEIGSKSQMALLDILLQS-----SINNQPLSDADIR 307

Human   297 AQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQ-MEYLDMV 359
            .:...|:|.|.:||||.:|..:|.:|.||:|||::.||:..|| |:.:.|.....|| ::|||.|
  Fly   308 EEVDTFMFEGDDTTSSGVSHALYAIARHPEVQQRIFEELQRVLGPDASAPVTQAQLQDLKYLDCV 372

Human   360 VNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK 424
            :.||:||:|....:.|..:|::||....||....:.:..|..|||..|:.:|..|.||||.:..:
  Fly   373 IKETMRLYPPVPAIGRHAQKELEIGDKTIPANTSIYLVLYYAHRDANYFPDPLSFRPERFLEDQE 437

Human   425 DNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP----LKLSLGGL--- 482
            ...:.:.|.||.:||:||||.:||::.||:.:.:||:.:...|..|...|    :..|..|:
  Fly   438 QGHNTFAYVPFSAGPKNCIGQKFAVLEMKVLISKVLRFYELLPLGEELKPMLNFILRSASGINVG 502

Human   483 LQPEK 487
            |:|.|
  Fly   503 LRPRK 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	CYP3A	67..492	CDD:410743	129/461 (28%)
Cyp4d20	NP_647723.2	CYP4	68..501	CDD:410721	124/451 (27%)