Protein Alignment CYP3A4 and Cyp6d2

DIOPT Version :9

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_611698.1
• Gene: Cyp6d2 / 37594
• FlyBaseID: FBgn0034756
• Length: 512
• Species: Drosophila melanogaster
• Alignment Length: 527
• Identity: 152/527 - (28%)
• Similarity: 262/527 - (49%)
• Gaps: 59/527 - (11%)

Human    12 WLLLAVSLV--LLYLYGTHSHGLFKKLGI---PGPTPLPFLGNILSYHKGFCMFDMECHKKY-GK 70
            |.:|...|:  |||.|....:..:::||:   |...|...:..::...:...|...:.:.:: ||
  Fly     2 WTILLTILIAGLLYRYVKRHYTHWQRLGVDEEPAKIPFGVMDTVMKQERSLGMALADIYARHEGK 66

Human    71 VWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEE---------- 125
            :.|.|...:..:.|.|..:.:.::..: ::.|.:|           .:.:.||::
  Fly    67 IVGIYMLNKRSILIRDAQLARQIMTSD-FASFHDR-----------GVYVDEDKDPLSANLFNLR 119

Human   126 ---WKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITST 187
               |:.||..|:|:|:|||:|.|...|...||.||::|....:....|.:|||...|::|:|.|.
  Fly   120 GASWRNLRQKLTPSFSSGKIKGMFGTIDDVGDKLVQHLEGALDQSDEVEIKDVMTTYAVDIIGSV 184

Human   188 SFGVNIDSLNNPQDPFVENTKKLLRFD--FLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLR 250
            .||:.|||..||::.|.|.:....|.:  .|....:|:.:.|   ||.:::|...:...:...||
  Fly   185 IFGLEIDSFRNPKNEFREISSSTSRDESLLLKIHNMSMFICP---PIAKLMNRLGYESRILTSLR 246

Human   251 KSVKRMKESRLEDTQKHRVDFLQLMIDSQNS------------KET--ESHKALSDLELVAQSII 301
            ..:||..|.| |:....|.|.|||:|..:|:            .||  |..|::|..::.||:.:
  Fly   247 DMMKRTIEFR-EEHNVVRKDMLQLLIRLRNTGKIGEDDDQVWDMETAQEQLKSMSIEKIAAQAFL 310

Human   302 FIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL--PNKAPP---TYDTVLQMEYLDMVVN 361
            |..||.|:|::..:|.:|||:.:|::.::.|||:||||  .|..|.   ||:.|..:::||:.:.
  Fly   311 FYVAGSESTAAASAFTLYELSMYPELLKEAQEEVDAVLMKHNLKPKDRFTYEAVQDLKFLDICIM 375

Human   362 ETLRLFPIAMRLERVCKKDVEINGM--FIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK 424
            ||:|.:|....|.|.|.:|..:.|.  .|.||..::|..:.:.|||.|:..|..:.|.||...|.
  Fly   376 ETIRKYPGLPFLNRECTEDYPVPGTNHIIAKGTPILISLFGMQRDPVYFPNPNGYDPHRFDSNNM 440

Human   425 DNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPV 489
             |.|...|.|||.|||:||.:|...:|.|:|:.::|.||........::..:.....:|..::|:
  Fly   441 -NYDQAAYMPFGEGPRHCIALRMGKVNSKVAVAKILANFDLVQSPRKEVEFRFDAAPVLVTKEPL 504

Human   490 VLKVESR 496
            .|::..|
  Fly   505 KLRLTKR 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	142/490 (29%)
Cyp6d2	NP_611698.1	p450	65..506	CDD:278495	138/457 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920