Protein Alignment CYP3A4 and Cyp317a1

DIOPT Version :10

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_611004.1
• Gene: Cyp317a1 / 36667
• FlyBaseID: FBgn0033982
• Length: 518
• Species: Drosophila melanogaster
• Alignment Length: 514
• Identity: 133/514 - (25%)
• Similarity: 248/514 - (48%)
• Gaps: 53/514 - (10%)

Human    13 LLLAVSLVLLYLYGTHSHGLFKKLGIPGPTP---LPFLGNILSYHKGFCMFDME----CHKKY-- 68
            ||:...||||.:...:....::.|.||...|   .|.:..|::..........|    .:||:
  Fly    10 LLVLGLLVLLIIAARYQRDYWRYLDIPHERPKKLWPIIRQIMTQTLSTEAMKAEHYSAIYKKFKG 74

Human    69 -GKVWGFYDGQQPVLAITDPDMIKTVLVKECYS-----VFTNRRPFGPVGFMKSAISIAEDEEWK 127
             |...|||...||...|.|.::|:.:::|:.::     ::.|::. .|   :...:.....|.||
  Fly    75 SGPFCGFYALLQPRALILDRELIRQIMIKDFWNFNDRGLYCNQKS-DP---LSGDLYALRGESWK 135

Human   128 RLRSLLSPTFTSGKLKEMVPIIAQYGD--VLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFG 190
            .:|..|.|:....::..:...:.:..:  :|..|....::....|.::.:...|.:..:....||
  Fly   136 EMRQKLDPSLEGDRMSLLYDCLYEEAEQLLLTVNSTLMSQPHSTVHIQKIMRRYVLSSLAKCVFG 200

Human   191 VNIDSLNN-PQDPFVENTKKLL---RFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRK 251
            :|.:.... |.:.|.:.|:..|   :..:|  ..|.:..||....:|.:...   |::...:..|
  Fly   201 LNAEQRKTYPLEDFEQMTELALNSHKHGYL--MNLMMIRFPNFCRMLRMRRT---PKQAEEYFIK 260

Human   252 SVKRMKESRLEDTQKHRVDFLQLMIDSQN----SKETESHKALS---DLELVAQSIIFIFAGYET 309
            .:..:.|.| |.:.|.:.|:|||:||.:.    :.:.|:.|.|.   ..||.|.:::|:.||||.
  Fly   261 LLTSIVEQR-ETSGKPQKDYLQLLIDVKALEFITHQYEADKELGAHLQNELAAHAVVFLKAGYEQ 324

Human   310 TSSVLSFIMYELATHPDVQQKLQEEI-DAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRL 373
            |::.||:::||||.||::|.:::||: .|:..:....|::.:..:.::..|:|||||:.||...:
  Fly   325 TANTLSYVLYELALHPELQVRVREEVKKAIERHDGHITHEGIKSLSFMGQVINETLRMHPITPYI 389

Human   374 ERVCKKDVEINGMFIPKGVVV-----MIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYT 433
            .|....|..:...  ||.::|     :||::|:|.||..:.:||:|.|:|:|.......:...:.
  Fly   390 LRRTLNDYAVPDH--PKYILVKELFLIIPTHAIHHDPDIYPDPEEFKPDRWSGPRDSLQEQGTWF 452

Human   434 PFGSGPRNCIGMRFALMNMKLALIRVLQNFSF-----KPC--KETQIPLKLSLGGLLQP 485
            .||.|.|:|||::||.:.::|||..:|..:.|     ||.  .|..|.|.|...|:::|
  Fly   453 GFGVGARSCIGIQFAQLQLRLALALLLSEYEFSLNTRKPLINLEDGIALTLMPLGVIEP 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	CYP3A	67..492	CDD:410743	119/453 (26%)
Cyp317a1	NP_611004.1	CYP6-like	74..509	CDD:410679	117/446 (26%)