DRSC/TRiP Functional Genomics Resources

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Protein Alignment CYP3A4 and Cyp317a1

DIOPT Version :9

Sequence 1:NP_059488.2 Gene:CYP3A4 / 1576 HGNCID:2637 Length:503 Species:Homo sapiens
Sequence 2:NP_001286435.1 Gene:Cyp317a1 / 36667 FlyBaseID:FBgn0033982 Length:518 Species:Drosophila melanogaster


Alignment Length:514 Identity:133/514 - (25%)
Similarity:248/514 - (48%) Gaps:53/514 - (10%)


- Green bases have known domain annotations that are detailed below.


Human    13 LLLAVSLVLLYLYGTHSHGLFKKLGIPGPTP---LPFLGNILSYHKGFCMFDME----CHKKY-- 68
            ||:...||||.:...:....::.|.||...|   .|.:..|::..........|    .:||:  
  Fly    10 LLVLGLLVLLIIAARYQRDYWRYLDIPHERPKKLWPIIRQIMTQTLSTEAMKAEHYSAIYKKFKG 74

Human    69 -GKVWGFYDGQQPVLAITDPDMIKTVLVKECYS-----VFTNRRPFGPVGFMKSAISIAEDEEWK 127
             |...|||...||...|.|.::|:.:::|:.::     ::.|::. .|   :...:.....|.||
  Fly    75 SGPFCGFYALLQPRALILDRELIRQIMIKDFWNFNDRGLYCNQKS-DP---LSGDLYALRGESWK 135

Human   128 RLRSLLSPTFTSGKLKEMVPIIAQYGD--VLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFG 190
            .:|..|.|:....::..:...:.:..:  :|..|....::....|.::.:...|.:..:....||
  Fly   136 EMRQKLDPSLEGDRMSLLYDCLYEEAEQLLLTVNSTLMSQPHSTVHIQKIMRRYVLSSLAKCVFG 200

Human   191 VNIDSLNN-PQDPFVENTKKLL---RFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRK 251
            :|.:.... |.:.|.:.|:..|   :..:|  ..|.:..||....:|.:...   |::...:..|
  Fly   201 LNAEQRKTYPLEDFEQMTELALNSHKHGYL--MNLMMIRFPNFCRMLRMRRT---PKQAEEYFIK 260

Human   252 SVKRMKESRLEDTQKHRVDFLQLMIDSQN----SKETESHKALS---DLELVAQSIIFIFAGYET 309
            .:..:.|.| |.:.|.:.|:|||:||.:.    :.:.|:.|.|.   ..||.|.:::|:.||||.
  Fly   261 LLTSIVEQR-ETSGKPQKDYLQLLIDVKALEFITHQYEADKELGAHLQNELAAHAVVFLKAGYEQ 324

Human   310 TSSVLSFIMYELATHPDVQQKLQEEI-DAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRL 373
            |::.||:::||||.||::|.:::||: .|:..:....|::.:..:.::..|:|||||:.||...:
  Fly   325 TANTLSYVLYELALHPELQVRVREEVKKAIERHDGHITHEGIKSLSFMGQVINETLRMHPITPYI 389

Human   374 ERVCKKDVEINGMFIPKGVVV-----MIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYT 433
            .|....|..:...  ||.::|     :||::|:|.||..:.:||:|.|:|:|.......:...:.
  Fly   390 LRRTLNDYAVPDH--PKYILVKELFLIIPTHAIHHDPDIYPDPEEFKPDRWSGPRDSLQEQGTWF 452

Human   434 PFGSGPRNCIGMRFALMNMKLALIRVLQNFSF-----KPC--KETQIPLKLSLGGLLQP 485
            .||.|.|:|||::||.:.::|||..:|..:.|     ||.  .|..|.|.|...|:::|
  Fly   453 GFGVGARSCIGIQFAQLQLRLALALLLSEYEFSLNTRKPLINLEDGIALTLMPLGVIEP 511

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CYP3A4NP_059488.2 p450 39..493 CDD:365848 125/488 (26%)
Cyp317a1NP_001286435.1 p450 39..466 CDD:299894 109/438 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D264519at33208
OrthoFinder 1 1.000 - - FOG0000037
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X40
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.920

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