DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP3A4 and Cyp6a8

DIOPT Version :9

Sequence 1:	NP_059488.2	Gene:	CYP3A4 / 1576	HGNCID:	2637	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	154/519 - (29%)
Similarity:	261/519 - (50%)	Gaps:	51/519 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    11 TWLLLAVSLVLLYLYGTHSH---GLFKKLGIPGPTPLPFLGNI--LSYHKGFCMFDMECHKKY-- 68
            |::|..|::.||.:...:.|   ..||:.|||...|....||:  |...|.......:.:.|:
  Fly     4 TYILFQVAVALLAILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNKFRE 68

Human    69 --GKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPF-----GPVGFMKSAISIAEDEEW 126
              ....||:..|.|...:.|.::.|.:|:|: :|.|:|:..|     .|:   .:.:...:..:|
  Fly    69 SKAPFVGFFFFQSPAAFVIDLELAKQILIKD-FSNFSNKGIFYNEKDDPI---SAHLFNLDGAQW 129

Human   127 KRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGV 191
            :.||:.||.||||||:|.|.|.:....:..:..:..:......:.::|:...:::|||.:.:||:
  Fly   130 RLLRNKLSSTFTSGKMKLMYPTVVSVANEFMTVMHEKVPKNSVLEIRDLVARFTVDVIGTCAFGI 194

Human   192 NIDSLNNPQDPFVENTKKLL----RFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKS 252
            ..:||.:.:..|:...|:.|    ....|:.|..|   :|.|...|.::...   ..:..|..:.
  Fly   195 QCNSLRDEKAEFLYFGKRSLVDKRHGTLLNGFMRS---YPKLARKLGMVRTA---PHIQEFYSRI 253

Human   253 VKRMKESRLEDTQKHRVDFLQLMIDSQNSKET-----ESHKALSDLELVAQSIIFIFAGYETTSS 312
            |......|.::..| |.||:.::|:.:|.||.     :..:.|:..|::||:.:|..||:||:||
  Fly   254 VTETVAVREKEHIK-RNDFMDMLIELKNQKEMTLENGDVVRGLTMEEVLAQAFVFFIAGFETSSS 317

Human   313 VLSFIMYELATHPDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLERV 376
            .:.|.:||||.:||:|.|::.|::.|:...... ||:....::||:.|::|||||:.|...|:|:
  Fly   318 TMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLDETLRLYTIVPNLDRM 382

Human   377 CKKDVEING---MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSG 438
            ..|...:.|   ..|..|..|:|||.|:|.||..:.||.:|.|||||.:.........:.|||.|
  Fly   383 AAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEESAGRPSVAWLPFGDG 447

Human   439 PRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVV-------LKVES 495
            ||||||:||..|..::.|..:::||.|..|.:|..||      :..|:..|:       ||||:
  Fly   448 PRNCIGLRFGQMQARIGLALLIRNFKFSTCSKTPNPL------VYDPKSFVLGVKDGIYLKVET 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	141/484 (29%)
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	140/480 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820