Protein Alignment CYP3A4 and Cyp6a21

DIOPT Version :10

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_611003.2
• Gene: Cyp6a21 / 36665
• FlyBaseID: FBgn0288232
• Length: 504
• Species: Drosophila melanogaster
• Alignment Length: 505
• Identity: 152/505 - (30%)
• Similarity: 259/505 - (51%)
• Gaps: 71/505 - (14%)

Human    11 TWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVW--- 72
            |.||..|..:|:....|..|  ::.||||...|...:|::    ||     :...:.:.::|
  Fly     9 TALLALVGYLLMKWRSTMRH--WQDLGIPCEEPHILMGSM----KG-----VRTARSFNEIWTSY 62

Human    73 -----------GFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGF--------MKSAI 118
                       |||..::|.:.:.:..:.|.:|:|| ::.||:|      ||        :...:
  Fly    63 YNKFRGSGPFAGFYWFRRPAVFVLETSLAKQILIKE-FNKFTDR------GFFHNPEDDPLSGQL 120

Human   119 SIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIA----QYGDVLVRNLRREAETGKPVT-LKDVFGA 178
            .:.:.::|:.:|:.||.||||||:|.|.|.:.    ::.||..:|:.:     .||. ::::...
  Fly   121 FLLDGQKWRTMRNKLSSTFTSGKMKYMFPTVVKVANEFTDVFGQNVAK-----SPVVEVRELLAR 180

Human   179 YSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLS-ITVFPFLIPILEVLNICVFP 242
            ::.|||.:.:||:...||.:|...|.|..::.|....|.|..:. :..||.|   ...|::.:..
  Fly   181 FTTDVIGTCAFGIECSSLKDPDAEFREMGRRSLTEQRLGPVGIGFVNSFPNL---ARRLHMKMTA 242

Human   243 REVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQN-----SKETESHKALSDLELVAQSIIF 302
            ..:..|..:.|:.....| |.....|.||:..:||.:|     |:..||.. |:..|:.||:.:|
  Fly   243 EPIERFFMRIVRETVAFR-EQNNIRRNDFMDQLIDLKNKPLMVSQSGESVN-LTIEEIAAQAFVF 305

Human   303 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN-KAPPTYDTVLQMEYLDMVVNETLRL 366
            ..||:||:|:.:.|.:||||.:.|:|.::::|...|:.. .....|:::..:.|||.||:|||||
  Fly   306 FAAGFETSSTTMGFALYELAQNQDIQNRVRKECQEVIEKCNGELNYESMKDLVYLDQVVSETLRL 370

Human   367 FPIAMRLERVCKKDVEING---MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK---KNKD 425
            :.:...|.|.|.:|.|:.|   ..|.||:.|:||..|:|||.|.:..|..|.|:.||.   |.:|
  Fly   371 YTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERD 435

Human   426 NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPL 475
            :::   :.|||.||||||||||..|..::.|..::::|.|..|::|.||:
  Fly   436 SVE---WLPFGDGPRNCIGMRFGQMQARIGLALLIKDFKFSVCEKTTIPM 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	CYP3A	67..492	CDD:410743	137/449 (31%)
Cyp6a21	NP_611003.2	CYP6-like	68..498	CDD:410679	136/435 (31%)