Protein Alignment CYP3A4 and Cyp6a9

DIOPT Version :10

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_523748.2
• Gene: Cyp6a9 / 36663
• FlyBaseID: FBgn0013771
• Length: 504
• Species: Drosophila melanogaster
• Alignment Length: 525
• Identity: 163/525 - (31%)
• Similarity: 262/525 - (49%)
• Gaps: 71/525 - (13%)

Human    13 LLLAVSLVLL-YLYGTHSHGL--FKKLGIPGPTPLPFLGNI--LSYHKGFCMFDMECHKKY---G 69
            :|||:.:||: ||.......|  ::.|.||...|...:|::  :...:.|....|:.:.|:   |
  Fly     6 VLLAIVVVLVGYLLLKWRRALHYWQNLDIPCEEPHILMGSLTGVQTSRSFSAIWMDYYNKFRGTG 70

Human    70 KVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGF--------MKSAISIAEDEEW 126
            ...|||..|:|.:.:.|..:.|.:|:|| ::.||:|      ||        :...:.:.:.::|
  Fly    71 PFAGFYWFQRPGILVLDISLAKLILIKE-FNKFTDR------GFYHNTEDDPLSGQLFLLDGQKW 128

Human   127 KRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGV 191
            |.:||.||.||||||:|.|.|.:.:.|...:....:..|....|.::|:...::.|||.:.:||:
  Fly   129 KSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPIVEVRDILARFTTDVIGTCAFGI 193

Human   192 NIDSLNNPQDPF--------VENTKKLLRFDFLDPF-------FLSITVFPFLIPILEVLNICVF 241
            ...||.:|:..|        .|.....:...|::.|       .:.||:
  Fly   194 ECSSLKDPEAEFRVMGRRAIFEQRHGPIGIAFINSFQNLARRLHMKITL---------------- 242

Human   242 PREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKA----LSDLELVAQSIIF 302
             .|..:|..:.|:.....| |.....|.||:..:||.:||..|:|...    |:..|:.||:.:|
  Fly   243 -EEAEHFFLRIVRETVAFR-EKNNIRRNDFMDQLIDLKNSPLTKSESGESVNLTIEEMAAQAFVF 305

Human   303 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN-KAPPTYDTVLQMEYLDMVVNETLRL 366
            ..||:||:|:.:.|.:||||.|.|:|.::::|...|:.. ....||:::..|.|||.|::|||||
  Fly   306 FGAGFETSSTTMGFALYELAQHQDIQDRVRKECQEVIGKYNGEITYESMKDMVYLDQVISETLRL 370

Human   367 FPIAMRLERVCKKDVEING---MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK---KNKD 425
            :.:...|.|.|.:|.|:.|   ..|.||:.|:||..|:|||.|.:..|..|.|:.||.   |.:|
  Fly   371 YTVLPVLNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERD 435

Human   426 NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGG-LLQPEKPV 489
            :::   :.|||.||||||||||..|..:..|..::..|.|..|::|.||:..|... |:..|..:
  Fly   436 SVE---WLPFGDGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTFLISSETGI 497

Human   490 VLKVE 494
            .||||
  Fly   498 FLKVE 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	CYP3A	67..492	CDD:410743	144/462 (31%)
Cyp6a9	NP_523748.2	CYP6-like	68..498	CDD:410679	143/457 (31%)