Protein Alignment CYP3A4 and Cyp6a19

DIOPT Version :10

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_611001.2
• Gene: Cyp6a19 / 36662
• FlyBaseID: FBgn0033979
• Length: 503
• Species: Drosophila melanogaster
• Alignment Length: 525
• Identity: 150/525 - (28%)
• Similarity: 257/525 - (48%)
• Gaps: 81/525 - (15%)

Human     1 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECH 65
            ||::..|.:....|:|..::..|.|       :|:.|||...|...|||.
  Fly     1 MAILLGLVVGVLTLVAWWVLQNYTY-------WKRRGIPHDPPNIPLGNT--------------- 43

Human    66 KKYGKVW-------------------------GFYDGQQPVLAITDPDMIKTVLVKECYSVFTNR 105
               |::|                         |||......:.|||.|.:||||::: :..|.:|
  Fly    44 ---GELWRTMPLAGILKRTYLKFRKQTDGPFAGFYLYAMKYIVITDVDFVKTVLIRD-FDKFHDR 104

Human   106 RPF-----GPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNL-RREA 164
            ..:     .|   :.:.::..|.::||.||..|:.||||.|:|.|...:...||.::|.: .:.:
  Fly   105 GVYHNEKDDP---LTNNLATIEGQKWKNLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKIS 166

Human   165 ETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFL 229
            .:.:.:.:.|:...::.|||...:||:..:||.:|:..||:.....|| :....:.:.:.:|.
  Fly   167 SSSQTLEVTDIVSRFTSDVIGICAFGLKCNSLRDPKAEFVQMGYSALR-ERRHGWLVDLLIFG-- 228

Human   230 IPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRV-------DFLQLMID-SQNSKETES 286
            :|.|.|       :....||..||::.....::||..:|:       ||:..:|| .|...:.:.
  Fly   229 MPKLAV-------KLGFQFLLPSVQKFYMKIVQDTIDYRMKRKVTRNDFMDTLIDMKQQYDKGDK 286

Human   287 HKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN-KAPPTYDTV 350
            ...|:..|:.||:.:|..||:|..|:.:.|.:||||.:.|||.||:.|||:||.. .....||::
  Fly   287 ENGLAFNEVAAQAFVFFLAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYNGKLEYDSM 351

Human   351 LQMEYLDMVVNETLRLFPIAMRLERVCKKDVEING--MFIPKGVVVMIPSYALHRDPKYWTEPEK 413
            ..:.|::.|:||:||..|:...|.|:..|..:.:.  .||..|..|::.:..:|.||:::.||||
  Fly   352 QDLFYMEKVINESLRKHPVVAHLARIATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEK 416

Human   414 FLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLS 478
            |:||||.::.........:.|||:|||||||:||..|.:.:.|..::.||.|:...:|.:|:|.:
  Fly   417 FIPERFDEEQVKKRPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFELHPKTPVPMKYT 481

Human   479 LGGLL 483
            :..||
  Fly   482 INNLL 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	CYP3A	67..492	CDD:410743	135/459 (29%)
Cyp6a19	NP_611001.2	CYP6-like	67..494	CDD:410679	133/434 (31%)