Protein Alignment CYP3A4 and Cyp9h1

DIOPT Version :10

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_610820.1
• Gene: Cyp9h1 / 36412
• FlyBaseID: FBgn0033775
• Length: 518
• Species: Drosophila melanogaster
• Alignment Length: 537
• Identity: 168/537 - (31%)
• Similarity: 273/537 - (50%)
• Gaps: 67/537 - (12%)

Human     6 DLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI--------LSYHKGFCMFDM 62
            |.:|....|..:.|||||.:....:.:|.:.|:....|.|.:|||        :...|..    :
  Fly     2 DQSMIALALFIILLVLLYKWSVAKYDVFSERGVSHEKPWPLIGNIPLKAMIGGMPVLKKM----I 62

Human    63 ECHKKY--GKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRP----FGPVGFMKSAISIA 121
            |.|.|:  ..|:|.|..:..|..:.||::||.:.:|| :..|.|...    .......||.||:
  Fly    63 ELHTKHTGSPVYGIYALRDAVFFVRDPELIKLIGIKE-FDHFVNHNSMHNNIQESILSKSLISL- 125

Human   122 EDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVT----LKDVFGAYSMD 182
            .|..||.:|::|:|.||..|::.|..:|....:..|.:::.:.|..:..:    :||.|..::.|
  Fly   126 RDGRWKEMRNILTPAFTGSKMRIMYDLIQSCSEEGVIHIQEQLELSQDASIELEMKDYFTRFAND 190

Human   183 VITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPF-FLSITVFPFL-----IPILEVLNICVF 241
            ||.:.:||::|:|.....:.|....:.:.|....... .:...:||.|     |.:|:..||..|
  Fly   191 VIATVAFGISINSFRRKDNEFFRIGQAMSRISAWSVVKAMLYALFPRLMKVLRIQVLDTKNIDYF 255

Human   242 PREVTNFLRKSVKRMKESRLEDTQKHRV---DFLQLMIDSQNSKETE-SHKALSDL--------E 294
            ...||..:|.            .|:|:|   |.:.|:::::..:..: |.|:..:|        :
  Fly   256 SSLVTAAMRY------------RQEHKVVRPDMIHLLMEAKQQRLADLSDKSKDELYYSEFTADD 308

Human   295 LVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAV---LPNKAPPTYDTVLQMEYL 356
            |:||.::|.|||:|..||.|.|:.:||..:|.||.:|.|||.:|   |..: |.|||.:.:|:||
  Fly   309 LLAQCLLFFFAGFEIISSSLCFLTHELCLNPTVQDRLYEEIISVHEELKGQ-PLTYDKLTKMKYL 372

Human   357 DMVVNETLRLFPIAMRLERVCKKDVEI---NGMFI---PKGVVVMIPSYALHRDPKYWTEPEKFL 415
            ||||.|.||.:|.::..:|.|::|:::   ||..:   .||.|:.||.::||.||:.:.:||.|.
  Fly   373 DMVVLEALRKWPPSISTDRECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHHDPENFEDPEFFN 437

Human   416 PERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 480
            ||||:..:.  ::..:|.|||.|||||||.|.|||.:|..:.::|.||...|.|.|...|...:.
  Fly   438 PERFADGHA--LESRVYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLLPAKRTSRDLLNDIR 500

Human   481 GL-LQPEKPVVLKVESR 496
            |. |:|:....||.|:|
  Fly   501 GHGLKPKNGFWLKFEAR 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	CYP3A	67..492	CDD:410743	146/462 (32%)
Cyp9h1	NP_610820.1	CYP6-like	69..511	CDD:410679	145/458 (32%)