DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP3A4 and Cyp6t3

DIOPT Version :9

Sequence 1:	NP_059488.2	Gene:	CYP3A4 / 1576	HGNCID:	2637	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_610745.1	Gene:	Cyp6t3 / 36318	FlyBaseID:	FBgn0033697	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	511	Identity:	141/511 - (27%)
Similarity:	243/511 - (47%)	Gaps:	50/511 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    12 WLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPF--LGNI-------LSYHKGFCMFDMECHKK 67
            |||| :::|.|..:..|.:..|:..|||...|..:  :||:       :|:...|.....:....
  Fly     5 WLLL-LTIVTLNFWLRHKYDYFRSRGIPHLPPSSWSPMGNLGQLLFLRISFGDLFRQLYADPRNG 68

Human    68 YGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAIS--IAEDEEWKRLR 130
            ..|:.||:..|.|.|.:.||::|:.||:|. ::.|.||......|....|::  :|:...||..|
  Fly    69 QAKIVGFFIFQTPALMVRDPELIRQVLIKN-FNNFLNRFESADAGDPMGALTLPLAKYHHWKESR 132

Human   131 SLLSPTFTSGKLK-----EMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFG 190
            ..:|..||||:::     :|:.:.:.....|.|.|....|...|  |..:...|:.||..:..:.
  Fly   133 QCMSQLFTSGRMRDVMYSQMLDVASDLEQYLNRKLGDRLERVLP--LGRMCQLYTTDVTGNLFYS 195

Human   191 VNIDSLNNPQDPFVENTKKLLR------FDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFL 249
            :|:..|...:...:..||:|..      .||:..|||     |....:|:       |:..|...
  Fly   196 LNVGGLRRGRSELITKTKELFNTNPRKVLDFMSVFFL-----PKWTGVLK-------PKVFTEDY 248

Human   250 RKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVL 314
            .:.::.:.:...|.|:...::.||....|::|.....|...    :.:|:.|.:.||:||:|:::
  Fly   249 ARYMRHLVDDHHEPTKGDLINQLQHFQLSRSSNHYSQHPDF----VASQAGIILLAGFETSSALM 309

Human   315 SFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKK 379
            .|.:||||..||:|::|:.|:.....:.|..:|||::.:.||.||..|.|||:|.|..:.|.|..
  Fly   310 GFTLYELAKAPDIQERLRSELREAFISTATLSYDTLMTLPYLKMVCLEALRLYPAAAFVNRECTS 374

Human   380 DVEIN-------GMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGS 437
            .....       ...:|.|:...|....||||.::|.||..|.||||..:...:|.|..|.|||:
  Fly   375 SASEGFSLQPHVDFIVPPGMPAYISILGLHRDERFWPEPCVFDPERFGPERSRHIHPMTYIPFGA 439

Human   438 GPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLS-LGGLLQPEKPVVLK 492
            ||..|||.|..::.:||.::.:|:.:..:.|:.|...::.: ...:|:.|..:.|:
  Fly   440 GPHGCIGSRLGVLQLKLGIVHILKQYWVETCERTVSEIRFNPKSFMLESENEIYLR 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	131/484 (27%)
Cyp6t3	NP_610745.1	p450	34..486	CDD:299894	127/470 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920