Protein Alignment CYP3A4 and Cyp6g2

DIOPT Version :10

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_610744.1
• Gene: Cyp6g2 / 36317
• FlyBaseID: FBgn0033696
• Length: 519
• Species: Drosophila melanogaster
• Alignment Length: 511
• Identity: 158/511 - (30%)
• Similarity: 269/511 - (52%)
• Gaps: 47/511 - (9%)

Human    13 LLLAVSLV-LLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYD 76
            |:|..||: :.:|.....:..::::|:....|...:||::    |.....|...:...:::...|
  Fly     6 LILVASLIGIAFLALQQHYSYWRRMGVREIRPKWIVGNLM----GLLNMRMSPAEFISQLYNHPD 66

Human    77 GQ-----------QPVLAITDPDMIKTVLVKECYSVFTNR----RPFG-PVGFMKSAISIAEDEE 125
            .:           :|.|.:.||:|::.:|||: ::.|:||    .|.| |:|  ...|...::..
  Fly    67 AENEPFVGIHVFHKPALLLRDPEMVRNILVKD-FAGFSNRYSSSDPKGDPLG--SQNIFFLKNPA 128

Human   126 WKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGK-----PVTLKDVFGAYSMDVIT 185
            ||.:|..|||.||..:||:|.|:|.:.|..|..:||::....:     .:..|::...|:.|||.
  Fly   129 WKEVRLKLSPFFTGNRLKQMFPLIEEVGASLDAHLRQQPLHNERMRCFDLEAKELCALYTTDVIA 193

Human   186 STSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVF-PFLIPILEVLNICVFPREVTNFL 249
            :.::||:.:|..:|:..|..:.:.:..|:.|.....::..| |.|:|.   :...|.|.|.|.||
  Fly   194 TVAYGVSANSFTDPKCEFRRHGRSVFEFNLLRAAEFTLVFFLPHLVPF---VRFKVVPAEATRFL 255

Human   250 RKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSD---LE---LVAQSIIFIFAGYE 308
            ||::..:...|.:..|| |.|.:.::|:.:.|.:......:.|   .|   ||||:::|..||:|
  Fly   256 RKTINYVMSEREKSGQK-RNDLIDILIEFRRSTQLAKASGIKDQFVFEGDILVAQAVLFFTAGFE 319

Human   309 TTSSVLSFIMYELATHPDVQQKLQEEI-DAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMR 372
            ::||.::|.|||||...||||:|:||| ||::.:....|...:..:|::.|::.|.||::|....
  Fly   320 SSSSTMAFAMYELAKDTDVQQRLREEIKDALVESGGQVTLKMIESLEFMQMILLEVLRMYPPLPF 384

Human   373 LERVCK--KDVEI----NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYI 431
            |:|.|.  :|..:    ....:|||:.|.||.||||.||:|:.:|.||||||||.:|:....||.
  Fly   385 LDRECTSGRDYSLAPFHKKFVVPKGMPVYIPCYALHMDPQYFPQPRKFLPERFSPENRKLHTPYT 449

Human   432 YTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEK 487
            |.|||.||..|||.||..:..|:.|:.:|:|......:.|...::|....::...|
  Fly   450 YMPFGLGPHGCIGERFGYLQAKVGLVNLLRNHMITTSERTPHRMQLDPKAIITQAK 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	CYP3A	67..492	CDD:410743	147/456 (32%)
Cyp6g2	NP_610744.1	CYP6-like	69..509	CDD:410679	146/444 (33%)