DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP3A4 and Cyp6g2

DIOPT Version :9

Sequence 1:	NP_059488.2	Gene:	CYP3A4 / 1576	HGNCID:	2637	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_610744.1	Gene:	Cyp6g2 / 36317	FlyBaseID:	FBgn0033696	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	511	Identity:	158/511 - (30%)
Similarity:	269/511 - (52%)	Gaps:	47/511 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    13 LLLAVSLV-LLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYD 76
            |:|..||: :.:|.....:..::::|:....|...:||::    |.....|...:...:::...|
  Fly     6 LILVASLIGIAFLALQQHYSYWRRMGVREIRPKWIVGNLM----GLLNMRMSPAEFISQLYNHPD 66

Human    77 GQ-----------QPVLAITDPDMIKTVLVKECYSVFTNR----RPFG-PVGFMKSAISIAEDEE 125
            .:           :|.|.:.||:|::.:|||: ::.|:||    .|.| |:|  ...|...::..
  Fly    67 AENEPFVGIHVFHKPALLLRDPEMVRNILVKD-FAGFSNRYSSSDPKGDPLG--SQNIFFLKNPA 128

Human   126 WKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGK-----PVTLKDVFGAYSMDVIT 185
            ||.:|..|||.||..:||:|.|:|.:.|..|..:||::....:     .:..|::...|:.|||.
  Fly   129 WKEVRLKLSPFFTGNRLKQMFPLIEEVGASLDAHLRQQPLHNERMRCFDLEAKELCALYTTDVIA 193

Human   186 STSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVF-PFLIPILEVLNICVFPREVTNFL 249
            :.::||:.:|..:|:..|..:.:.:..|:.|.....::..| |.|:|.   :...|.|.|.|.||
  Fly   194 TVAYGVSANSFTDPKCEFRRHGRSVFEFNLLRAAEFTLVFFLPHLVPF---VRFKVVPAEATRFL 255

Human   250 RKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSD---LE---LVAQSIIFIFAGYE 308
            ||::..:...|.:..|| |.|.:.::|:.:.|.:......:.|   .|   ||||:::|..||:|
  Fly   256 RKTINYVMSEREKSGQK-RNDLIDILIEFRRSTQLAKASGIKDQFVFEGDILVAQAVLFFTAGFE 319

Human   309 TTSSVLSFIMYELATHPDVQQKLQEEI-DAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMR 372
            ::||.::|.|||||...||||:|:||| ||::.:....|...:..:|::.|::.|.||::|....
  Fly   320 SSSSTMAFAMYELAKDTDVQQRLREEIKDALVESGGQVTLKMIESLEFMQMILLEVLRMYPPLPF 384

Human   373 LERVCK--KDVEI----NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYI 431
            |:|.|.  :|..:    ....:|||:.|.||.||||.||:|:.:|.||||||||.:|:....||.
  Fly   385 LDRECTSGRDYSLAPFHKKFVVPKGMPVYIPCYALHMDPQYFPQPRKFLPERFSPENRKLHTPYT 449

Human   432 YTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEK 487
            |.|||.||..|||.||..:..|:.|:.:|:|......:.|...::|....::...|
  Fly   450 YMPFGLGPHGCIGERFGYLQAKVGLVNLLRNHMITTSERTPHRMQLDPKAIITQAK 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	152/484 (31%)
Cyp6g2	NP_610744.1	p450	36..511	CDD:278495	152/481 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920