Protein Alignment CYP3A4 and Cyp6g1

DIOPT Version :10

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_610743.2
• Gene: Cyp6g1 / 36316
• FlyBaseID: FBgn0025454
• Length: 524
• Species: Drosophila melanogaster
• Alignment Length: 518
• Identity: 173/518 - (33%)
• Similarity: 282/518 - (54%)
• Gaps: 46/518 - (8%)

Human    10 ETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYG----- 69
            |...::..:||.||.:...:|..:::.|||...|.|.:||.....|....|.|...:.|.
  Fly     5 EVLFVVVAALVALYTWFQRNHSYWQRKGIPYIPPTPIIGNTKVVFKMENSFGMHLSEIYNDPRLK 69

Human    70 --KVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNR----RPFG-PVGFMKSAISIAEDEEWK 127
              .|.|.|...:|.|.|.|.::||::|:|: ::.|.||    .|.| |:|:  :.:....|..||
  Fly    70 DEAVVGIYSMNKPGLIIRDIELIKSILIKD-FNRFHNRYARCDPHGDPLGY--NNLFFVRDAHWK 131

Human   128 RLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAE--TGKPVT-LKDVFGAYSMDVITSTSF 189
            .:|:.|:|.|||||:|:|..::.:.|..|...|:|..|  :|..:| :|::...:|.|.|.:.:|
  Fly   132 GIRTKLTPVFTSGKVKQMYTLMQEIGKDLELALQRRGEKNSGSFITEIKEICAQFSTDSIATIAF 196

Human   190 GVNIDSLNNPQDPFVENTKKLLRF------DFLDPFFLSITVFPFLIPILEVLNICVFPREVTNF 248
            |:..:||.||...|....:|:..|      ||...|||     |.|:   .::.|..|..:.::|
  Fly   197 GIRANSLENPNAEFRNYGRKMFTFTVARAKDFFVAFFL-----PKLV---SLMRIQFFTADFSHF 253

Human   249 LRKSVKRMKESRLEDTQKHRVDFLQLMIDSQN---SKETESHKALSDLELVAQSIIFIFAGYETT 310
            :|.::..:.|.| |.:...|.|.:.:::..:.   ::.::.|.|.:...||||:.:|..||:||:
  Fly   254 MRSTIGHVMEER-ERSGLLRNDLIDVLVSLRKEAAAEPSKPHYAKNQDFLVAQAGVFFTAGFETS 317

Human   311 SSVLSFIMYELATHPDVQQKLQEEI-DAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLE 374
            ||.:||.:||:|.||::|::|::|| :|::......:|:.:..:|||.|||:|.||::|:...|:
  Fly   318 SSTMSFALYEMAKHPEMQKRLRDEINEALVEGGGSLSYEKIQSLEYLAMVVDEVLRMYPVLPFLD 382

Human   375 RVCKK-----DVEINGMF---IPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYI 431
            |..:.     |:.:...:   :..|..|.||.||||.||||||.|.:|.|||||..|:.||....
  Fly   383 REYESVEGQPDLSLKPFYDYTLENGTPVFIPIYALHHDPKYWTNPSQFDPERFSPANRKNIVAMA 447

Human   432 YTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLS-LGGLLQPEKPVVLKV 493
            |.||||||.||||.|..|:..||.|:.:|:|.|.:.|:.|...:|.. .|.:||.:..:.|::
  Fly   448 YQPFGSGPHNCIGSRIGLLQSKLGLVSLLKNHSVRNCEATMKDMKFDPKGFVLQADGGIHLEI 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	CYP3A	67..492	CDD:410743	156/458 (34%)
Cyp6g1	NP_610743.2	CYP6-like	69..507	CDD:410679	155/449 (35%)