Protein Alignment CYP3A4 and Cyp6a13

DIOPT Version :9

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_610390.1
• Gene: Cyp6a13 / 35837
• FlyBaseID: FBgn0033304
• Length: 493
• Species: Drosophila melanogaster
• Alignment Length: 502
• Identity: 162/502 - (32%)
• Similarity: 279/502 - (55%)
• Gaps: 30/502 - (5%)

Human     9 METWLLLAVSL-VLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFD--MECHKKYGK 70
            |.|.|:|..:: :|||:.....:..:.:.|:.|..|:.|.||:....:.....|  :..::|:..
  Fly     1 MLTLLVLVFTVGLLLYVKLRWHYSYWSRRGVAGERPVYFRGNMSGLGRDLHWTDINLRIYRKFRG 65

Human    71 V---WGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPV--GFMKSAISIAEDEEWKRLR 130
            |   .|::......|.|.|.::|:.::::: :|.|.:|..|..|  ..:...:...:..||:.||
  Fly    66 VERYCGYFTFMTKSLFIMDLELIRDIMIRD-FSSFADRGLFHNVRDDPLTGNLLFLDGPEWRWLR 129

Human   131 SLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDS 195
            ..|:..|||||:|.|.|.:.:.|:.|.:..|  .:.|: :..||:...::.|||.|.:||:..:|
  Fly   130 QNLTQVFTSGKMKFMFPNMVEVGEKLTQACR--LQVGE-IEAKDLCARFTTDVIGSCAFGLECNS 191

Human   196 LNNPQDPFVENTKKLLRFDFLDPFF-LSITVFPFLIP-ILEVLNICVFPREVTNFLRKSVKRMKE 258
            |.:|:..|    :::.|....:|.. :.:..|.|..| :...|...:|..||:.|...:|::..:
  Fly   192 LQDPESQF----RRMGRSVTQEPLHSVLVQAFMFAQPELARKLRFRLFRPEVSEFFLDTVRQTLD 252

Human   259 SRLEDTQKHRVDFLQLMID--SQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYEL 321
            .|..: ..||.|.:||:::  .:..|:     |||..::.||:::|..||::|:|:.:||.:|||
  Fly   253 YRRRE-NIHRNDLIQLLMELGEEGVKD-----ALSFEQIAAQALVFFLAGFDTSSTTMSFCLYEL 311

Human   322 ATHPDVQQKLQEEIDAVLP-NKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI-- 383
            |.:||||::|:.|:.|||. |....|||:|.:|.|||.||.||||.:||...|.|...|:.:|
  Fly   312 ALNPDVQERLRVEVLAVLKRNNQKLTYDSVQEMPYLDQVVAETLRKYPILPHLLRRSTKEYQIPN 376

Human   384 NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFA 448
            :.:.:..|..::||.:::|.||:.:.:||||.|.||..:......|:.|.|||.|||||||.||.
  Fly   377 SNLILEPGSKIIIPVHSIHHDPELYPDPEKFDPSRFEPEEIKARHPFAYLPFGEGPRNCIGERFG 441

Human   449 LMNMKLALIRVLQNFSFKPCKETQIPLKLSLGG-LLQPEKPVVLKVE 494
            .:.:|:.|:.:|::|.|...::||||||.|... |:..::.|.|::|
  Fly   442 KLQVKVGLVYLLRDFKFSRSEKTQIPLKFSSRNFLISTQEGVHLRME 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	153/468 (33%)
Cyp6a13	NP_610390.1	p450	33..476	CDD:278495	150/456 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820