Protein Alignment CYP3A4 and Cyp6u1

DIOPT Version :10

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_610252.3
• Gene: Cyp6u1 / 35608
• FlyBaseID: FBgn0033121
• Length: 488
• Species: Drosophila melanogaster
• Alignment Length: 1410
• Identity: 294/1410 - (20%)
• Similarity: 460/1410 - (32%)
• Gaps: 409/1410 - (29%)

Human   911 HLQNLRLDSGPSPASPLSSISAPNSTDATHLKFHPVFVPHSAPAVLTNSNENRSNCVFEFHAQTP 975
            |.|.|.::|.....|. ..:...:|..|...|:..::..|.....|   |:|..:.:.:.   ..
  Fly    21 HTQLLAMESACLQESD-RQVELEDSIIAWQDKYERLYESHKRVQKL---NQNLEDKLLKL---VD 78

Human   976 SSSGEGGGILPQRVYRNRQVAVDSNQEELSPQSVGLHCHLQPVTEEQRNNHAPELTISVVEPMGQ 1040
            .:|||             :..:.|:...||.:....:.::|.:   :|.....:..|||...:.|
  Fly    79 RNSGE-------------RAQLTSDVATLSVRLAQANYNIQSL---KREIERYKTDISVAIQLLQ 127

Human  1041 IWP--IGSPEYSSDSSQITSSDLS----DFQSPPPTGGTAAPFGSDVSLPFIRLPQTVLQESPLF 1099
            ..|  ..||:.||...:|.|...:    |..|...:.|:.:..|...:..:..||.:   :||..
  Fly   128 CKPDSFVSPKLSSLPIEIQSKVATYMRLDTNSHSDSEGSTSGVGMATTNSYHVLPAS---DSPPP 189

Human  1100 FC-FPQGTTSQQVLSASYSSGGSTLHPQAQGQNQGQPSSSLAGVLSSQPIQHPQQQGIQPTVPSQ 1163
            .| ||   .:..|.|.....|||     ..||..|...|:           |.|::      ||.
  Fly   190 ICPFP---PTAMVYSMRGLDGGS-----QDGQLPGGKQSN-----------HGQRE------PSG 229

Human  1164 QAVQYSLPQAASSSEGTTAQPVSQPQVSAGTQLPVSQTVATVQGEPHIPVSTQPSVVPVHSGAHF 1228
            |..|..|.|.|         |:..|   .||...|.....::.|:....||  |||:     |.|
  Fly   230 QQQQQQLQQEA---------PLVVP---LGTTPAVPGATDSLLGDGQNVVS--PSVM-----AKF 275

Human  1229 LP---------MGQPI---PTSLLPQYPVSQIPISTPHVS----------TAQTGFSSVPITM-- 1269
            |.         :|.||   .|.:.||.....:..:..|.|          :.|..:|....|:
  Fly   276 LEDELKSSDALLGTPIKHCDTCVCPQGGGGAVESARLHASGSLLLADLLGSDQKYYSVATQTLVR 340

Human  1270 ---AAGINQPLLTLASSATASSIPGGSPVVPNQLPTLLQPVNQLQSQVH-----PQLLQPTTVQS 1326
               |.|.|..|....||...|.....||.:...:.:....:::.:|.|.     |..:.|||...
  Fly   341 GEHANGTNTLLCLRCSSNLNSPSHHNSPYMLKLIKSSDSVISETKSSVSDYLTTPDKVSPTTAVR 405

Human  1327 IGIPAN------LGQAAEGPLPSGDVLYQGFPSRLPPQYPGDSNIAPSSNVASVCI-HSTVLAPP 1384
            .|..||      :|...||...|..:.....|::     ..|..:.|......:.: .||.|:..
  Fly   406 PGGSANGAACGDIGTGGEGSDTSDPLALLVVPTK-----KDDLMVNPILGHHRLAVERSTALSAN 465

Human  1385 SMPTEALATQ----------GYFPTVVQPYV----------ESTPLVPMGSVGGQVQVSQPAVSL 1429
            ......|..|          |..||..|.:.          :|.|.|..|| ||..|::.   .|
  Fly   466 QTDQHHLQQQQQQQHNKLAAGKVPTTTQQHTKKLPGDTAFKQSKPPVCGGS-GGAGQMTP---QL 526

Human  1430 TQQPPTTS-----SQQAVLESTQGVSQAAPPEQTPITQSQPTQPV--PLVTSADSAHSDVASGM- 1486
            ::..||.|     |...:::.|   .|.:....|||:.|.....|  |......||...|.||:
  Fly   527 SRAEPTASKLAHDSPSYIIKDT---DQMSGSHATPISSSTGNGGVAGPSGKYGTSASGSVGSGLY 588

Human  1487 -SDGNENA---------PSSSGRHEGRTTKRHYRKSVRSRSRHEKTSRPKLRILNVSNKG----- 1536
             :.|:.|:         |...|........|:..|::  ::.:.|.|.|::..|.:.|..
  Fly   589 HTVGSTNSLWSRTSSKDPEKDGAKMFEIFNRNLIKTI--KAENPKMSGPRICALRIQNGSSNILL 651

Human  1537 DRVVECQLETHNRKMVTFKFDLDGDNPEEIATIMVNNDFILAIERESFVAQVREIIEKADE--ML 1599
            |.:|:..||           .||...|..          ::...|..|:          ||  :|
  Fly   652 DNLVDDGLE-----------GLDSKPPTP----------VMYTRRAKFL----------DEELLL 685

Human  1600 SEDVSVEPEGDQGLESLQGKDDYGFPGSQKLEGEFKQPIAVSSMPQQIGVPTSSLTQVVHSAGRR 1664
            .:|.|:                 |..|:          |..:::|    ..|||...:...||
  Fly   686 DDDPSI-----------------GLNGA----------IKTTNLP----TATSSGESISPPAG-- 717

Human  1665 FIVSPVPESRLRESKVFTSDISDPVVASTSQAPGMNL---------SHSASSLSLQQAFSELKHG 1720
                            :|..::.||  .:|||.|..|         .|.:..........|...|
  Fly   718 ----------------YTKPMTTPV--KSSQAAGGALGPAGDGGPDGHGSLISGTINRVDEGGGG 764

Human  1721 QMTEGPNTAPP------NFNHMAGPTFSPFLASIA-GVQTVAASTP--SVSVPITSSPLNDISTS 1776
            :...|...|..      |.:....|..|..|.:|. .|..:..:|.  :.::|   .|..||:.:
  Fly   765 EAARGHEEAGGGSKQVCNMSTTTSPHSSDRLCTIGEEVSNLLINTKLGTAALP---KPRLDINVN 826

Human  1777 VMQSETALPTEKGIVGVTTTSTGVVASGGLTTMSVSESPTSSSAVSS---------------STV 1826
            .::            |:..||              .:|.|.||::||               |.|
  Fly   827 KLE------------GIDVTS--------------KKSCTQSSSISSEIDLQESAILRRQQLSRV 865

Human  1827 PAVV----TVSTPSQPVQASTSGSIASSTGSFPPGTFSTTTATTMGSVVAPDAKPPTVLLQQVAS 1887
            ...|    .:...::|:..:.|.:..::.|:....:.: ..||..|  :.|.|..|||  .....
  Fly   866 AEWVQNNSKLGNAAEPLSNTESDNEPTAGGALTADSLN-NNATAPG--LPPKASRPTV--PSTGG 925

Human  1888 NTAGVAIVTSVSTT-TPF--PGMASQPSLPLSSSTSAPTLAETMVVSAHSLDKASHSSTAGL--G 1947
            ..||.....|:... .|:  ||..|  ||...:..||.|....|     :..|...|.|||.  |
  Fly   926 KPAGCEAKPSMGRLGHPYGPPGTGS--SLLNGNYASAATFGGGM-----NAPKPDRSITAGAKHG 983

Human  1948 LSFCAPSSSSSSGTAVSTSVSQPGMVHPLVISSAVVSTPGLPQPVVPTSTPL--LPQVPNIPPLV 2010
            .|....|||..:|||     |..|::.  ..|:|....||      |:|..|  :.:...:..|.
  Fly   984 YSNNLNSSSLPNGTA-----SASGLLD--YNSNATTVAPG------PSSAALGAIRKGSTVTVLR 1035

Human  2011 QPVVNVPAVQQTLIHSQPQPALLPNQPHTHCPEMDADTQSKAPGIDDIKTLEEKLRSLFSEHSSS 2075
            ...:    ..|.|...:.:.|.||: |..|.|..:.|....:..: |:..:|..::....:.:..
  Fly  1036 DSAL----TGQCLAGDERRLAPLPD-PDPHHPAGNDDDDDDSSSV-DLAQMEYNVKQFLLKQNEW 1094

Human  2076 GTQHASVSLETPLVVETTVTPGITTTAVAPSKLMTSTTSTCLPPTSLPLGAAG-MPVMPVGTP-- 2137
            .|                         |....|::|:.|:.       .|..| .||.||..|
  Fly  1095 ST-------------------------VRRQSLISSSASSV-------KGRGGDEPVRPVRDPCT 1127

Human  2138 ----------GQVSTPGTHASAPVGTATGVKPGTT---PPKPTKT 2169
                      .|...|..|.|...|.......|.:   |..|.:|
  Fly  1128 KGLFPGMAVAQQTQAPYQHHSGTTGVGGSNMYGNSHKYPINPHRT 1172

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	CYP3A	67..492	CDD:410743
Cyp6u1	NP_610252.3	CYP6-like	69..479	CDD:410679	103/480 (21%)