DRSC/TRiP Functional Genomics Resources

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Protein Alignment CYP3A4 and Cyp6u1

DIOPT Version :9

Sequence 1:NP_059488.2 Gene:CYP3A4 / 1576 HGNCID:2637 Length:503 Species:Homo sapiens
Sequence 2:NP_001286149.1 Gene:Cyp6u1 / 35608 FlyBaseID:FBgn0033121 Length:488 Species:Drosophila melanogaster


Alignment Length:508 Identity:139/508 - (27%)
Similarity:245/508 - (48%) Gaps:39/508 - (7%)


- Green bases have known domain annotations that are detailed below.


Human     6 DLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSY-----HKGFCMFDM-EC 64
            ||...|.|....:|.::|.....|.|.:|:.||....|....|||...     |....:.|: ..
  Fly     2 DLMHRTLLTALGALSVVYALVKFSLGYWKRRGILHEKPKFLWGNIKGVVSGKRHAQDALQDIYTA 66

Human    65 HKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPF-GPVGFMKSAISIAED-EEWK 127
            :|......|||...:|.:...|..::..::..:. ..||:|..: .|.|...|...:..| .:|:
  Fly    67 YKGRAPFVGFYACLKPFILALDLKLVHQIIFTDA-GHFTSRGLYSNPSGEPLSHNLLQLDGHKWR 130

Human   128 RLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNL-RREAETGKPVTLKDVFGAYSMDVITSTSFG- 190
            .|.:..:..||...:::::..::|....:.|:| .:..:|   :.:.::.|||:.||:.|.:|| 
  Fly   131 SLHAKSAEVFTPANMQKLLVRLSQISSRIQRDLGEKSLQT---INISELVGAYNTDVMASMAFGL 192

Human   191 VNIDSLNNPQDPFVENTKKLLRFDF-LDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRK-SV 253
            |..|::.     |.:.|:.... || :...:|::. ||.:..:|:..:   :....|.:.:| ::
  Fly   193 VGQDNVE-----FAKWTRNYWA-DFRMWQAYLALE-FPLIARLLQYKS---YAEPATAYFQKVAL 247

Human   254 KRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIM 318
            .:::..|..|.|..:. ||||.        :.:.|.|:|:|:..|:..|:.||....::.|:|.:
  Fly   248 SQLQLHRRRDRQPLQT-FLQLY--------SNAEKPLTDIEIAGQAFGFVLAGLGPLNATLAFCL 303

Human   319 YELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVE 382
            ||||..|:||.:.:.||:..| .:....|.:.:.::.|...|:||||||......|.|...|:.|
  Fly   304 YELARQPEVQDRTRLEINKALEEHGGQVTPECLRELRYTKQVLNETLRLHTPHPFLLRRATKEFE 368

Human   383 ING--MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGM 445
            :.|  ..|.||..|:||:.|:|.||..:..|::|.||||.::.:.:.....:.|||.|.|.||..
  Fly   369 VPGSVFVIAKGNNVLIPTAAIHMDPGIYENPQRFYPERFEEQARRSRPAAAFLPFGDGLRGCIAA 433

Human   446 RFALMNMKLALIRVLQNFSFKPCKETQIPLKL-SLGGLLQPEKPVVLKVESRD 497
            |||...:.:.|:.:|:...:.|..||.||::. :...||.|:..:.|.||..|
  Fly   434 RFAEQQLLVGLVALLRQHRYAPSAETSIPVEYDNRRLLLMPKSDIKLSVERVD 486

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CYP3A4NP_059488.2 p450 39..493 CDD:365848 125/469 (27%)
Cyp6u1NP_001286149.1 p450 38..475 CDD:299894 123/459 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D264519at33208
OrthoFinder 1 1.000 - - FOG0000037
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X40
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.920

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