Protein Alignment CYP3A4 and Cyp4ac3

DIOPT Version :10

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_608918.1
• Gene: Cyp4ac3 / 33756
• FlyBaseID: FBgn0031695
• Length: 509
• Species: Drosophila melanogaster
• Alignment Length: 495
• Identity: 127/495 - (25%)
• Similarity: 222/495 - (44%)
• Gaps: 73/495 - (14%)

Human    38 IPGPT----PLPFL----GNILSYHKGFCMFDMECHKKYGK--VWGF-YDGQQPVLAITDPDMI- 90
            :||.|    .|..|    .||.||.:      ....|..|:  :|.| :..:..::...|.:.|
  Fly    50 VPGKTRFGNNLDLLNLTPANIFSYIR------ESTAKANGQNYIWNFLFAPEYNIVRAEDAEEIF 108

Human    91 ---KTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQY 152
               |.......|.:.   ||     |:...:.|:.|::|...|..|:|.|....|:..:.|..:.
  Fly   109 QSTKITTKNMSYELI---RP-----FLGDGLLISIDQKWHTRRKTLTPAFHFNILQSFLSIFKEE 165

Human   153 GDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQD--------PFVENTKK 209
            ....::.|  :...|..:.|..:...::::.|..|:.||.:|.::...:        ..|.|.:.
  Fly   166 SKKFIKIL--DKNVGFELELNQIIPQFTLNNICETALGVKLDDMSEGNEYRKAIHDFEIVFNQRM 228

Human   210 LLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFL-- 272
            .....|.:.:|.....:.....||         |.:..|....::| |..:.:..|..:||..
  Fly   229 CNPLMFFNWYFFLFGDYKKYSRIL---------RTIHGFSSGIIQR-KRQQFKQKQLGQVDEFGK 283

Human   273 ---QLMIDSQNSKETE---SHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKL 331
               ..|:|:..:.|.|   .|:.:.|     :...|:|.||:|||:.|.|.:..||.|.|||::.
  Fly   284 KQRYAMLDTLLAAEAEGKIDHQGICD-----EVNTFMFGGYDTTSTSLIFTLLLLALHADVQERC 343

Human   332 QEEIDAVLPNKAPPTYDTVLQMEY-----LDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKG 391
            .||:..:     |...|.|...::     |:.|:.|:|||||.|..:.|.|.::..:||:.:||.
  Fly   344 YEELQDL-----PEDIDEVSMFQFNELIHLECVIKESLRLFPSAPIIGRTCIEESVMNGLVLPKN 403

Human   392 VVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLAL 456
            ..:.|..|.:.||.:::.:|.:||||||..:|..|..|:.:.||.:|||||||.:|.::.:|:.|
  Fly   404 AQISIHIYDIMRDARHFPKPNQFLPERFLPENSVNRHPFAFVPFSAGPRNCIGQKFGVLEIKVLL 468

Human   457 IRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 496
            ..|::||...|..:.: .|....|.:|:.::.:.:|.|:|
  Fly   469 AAVIRNFKLLPATQLE-DLTFENGIVLRTQQNIKVKFEAR 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	CYP3A	67..492	CDD:410743	114/452 (25%)
Cyp4ac3	NP_608918.1	CYP4	87..502	CDD:410721	113/445 (25%)