DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP3A4 and Cyp4ac1

DIOPT Version :9

Sequence 1:	NP_059488.2	Gene:	CYP3A4 / 1576	HGNCID:	2637	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_608916.1	Gene:	Cyp4ac1 / 33754	FlyBaseID:	FBgn0031693	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	141/535 - (26%)
Similarity:	242/535 - (45%)	Gaps:	89/535 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    13 LLLAVSLVLLYLYGTH-------------SHGLFKKLGI-PGPTPLPFLGN---ILSYHKG--FC 58
            ||..::|:|.::..|:             ...|..|:.| ||.|.   .||   ||::...  |.
  Fly    11 LLAVLTLLLKHINKTYFILSLTKRVRTEDGSPLESKVAIMPGKTR---FGNNLDILNFTPASVFN 72

Human    59 MFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTV------LVKECYSVFTNRRPFGPVGFMKSA 117
            .......|..|:.:.:|....|:..:..|:..:.|      :.|..  |:...||     |:...
  Fly    73 FVRESTAKAKGQNYLWYFLYAPMYNVVRPEEAEEVFQSTKLITKNV--VYELIRP-----FLGDG 130

Human   118 ISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQ----YGDVLVRNLRREAETGKPVTLKDVFGA 178
            :.|:.|.:|...|..|:|.|....|:..:.|..:    :.:||.:||..|.|      |..|...
  Fly   131 LLISTDHKWHSRRKALTPAFHFNVLQSFLGIFKEECKKFLNVLEKNLDAELE------LNQVIPP 189

Human   179 YSMDVITSTSFGVNIDSLN--NPQDPFVENTKKLLRFDFLDP-------FFLSITVFPFLIPILE 234
            ::::.|..|:.||.:|.::  |.....:...:::|.....:|       ||    |:......|:
  Fly   190 FTLNNICETALGVKLDDMSEGNEYRKAIHAIEEVLIQRVCNPLMYYNWYFF----VYGDYRKHLQ 250

Human   235 VLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFL-----QLMIDSQNSKETE---SHKALS 291
            .|.|      |.:|..:.::| |..:.:..|...||..     ..|:|:..:.|.:   .|:.:.
  Fly   251 NLRI------VHDFSSRIIER-KRQQFQQKQLGEVDEFGRKQRYAMLDTLLAAEADGQIDHQGIC 308

Human   292 DLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQME-- 354
            |     :...|:|.||:|||:.|.|.:..||.|.|||:|..||::     ..|...|.:...:
  Fly   309 D-----EVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEVE-----NLPEDSDDISMFQFN 363

Human   355 ---YLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLP 416
               ||:.|:.|:||:||....:.|.|.::..:|||.:||...:.|..|.:.|||:::.:|:.|.|
  Fly   364 KLVYLECVIKESLRMFPSVPFIGRQCVEETVVNGMVMPKDTQISIHIYDIMRDPRHFPKPDLFQP 428

Human   417 ERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGG 481
            :||..:|..|..|:.|.||.:|.|||||.:||::.||:.|..|::||...|..:.: .|....|.
  Fly   429 DRFLPENTVNRHPFAYVPFSAGQRNCIGQKFAILEMKVLLAAVIRNFKLLPATQLE-DLTFENGI 492

Human   482 LLQPEKPVVLKVESR 496
            :|:.::.:.:|:..|
  Fly   493 VLRTQENIKVKLSKR 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	131/490 (27%)
Cyp4ac1	NP_608916.1	p450	86..504	CDD:278495	121/452 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910