DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP3A4 and Cyp28d1

DIOPT Version :9

Sequence 1:	NP_059488.2	Gene:	CYP3A4 / 1576	HGNCID:	2637	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	495	Identity:	136/495 - (27%)
Similarity:	238/495 - (48%)	Gaps:	64/495 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    14 LLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSY--HKGFCMFDM----ECHKKYGKVW 72
            ::|..|.|:|::.|.:...:||.|||.....||:|:..|.  .|...::|:    |.:|....:.
  Fly    10 VIAAILALIYVFLTWNFSYWKKRGIPTAKSWPFVGSFPSVFTQKRNVVYDIDEIYEQYKNTDSIV 74

Human    73 GFYDGQQPVLAITDPDMIKTVLVKECYSVFTN---------------RRPFGPVGFMKSAISIAE 122
            |.:..:.|.|.:|.|:....:.|.:..|...|               ..||           :..
  Fly    75 GVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNEMAKFTDSKTDPILANNPF-----------VLT 128

Human   123 DEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREA--ETGKPVTLKDVFGAYSMDVIT 185
            .|.||..|:.::|..::.::|...|:..:.....|..:||::  ...:.:..||:...|:.:||:
  Fly   129 GEAWKERRAEVTPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQGLNAKDLCLCYTTEVIS 193

Human   186 STSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSI-TVFPFLIPILEVLNICVFPREVTNF- 248
            ....|::..|..:...|.|..||::....|...|:..: .::|   ||.:..::.:|.::|..|
  Fly   194 DCVLGISAQSFTDNPTPMVGMTKRVFEQSFGFIFYTVVANLWP---PITKFYSVSLFAKDVAAFF 255

Human   249 ---LRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETT 310
               ::|.::..:||   ...:.|.|||..|:..|..      |.|:..||.:.::.|:..|:|||
  Fly   256 YDLMQKCIQVRRES---PAAQQRDDFLNYMLQLQEK------KGLNAAELTSHTMTFLTDGFETT 311

Human   311 SSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLER 375
            :.||:..:..||.:|..|.||:|||     ..|..|::.:.::.:.:..::||||:|...:...:
  Fly   312 AQVLTHTLLFLARNPKEQMKLREEI-----GTAELTFEQISELPFTEACIHETLRIFSPVLAARK 371

Human   376 VCKKDVEI---NGMFIP--KGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKN---KDNIDPYIY 432
            |..:..|:   ||:.:.  .|.||:||..|||.||:|:.||:.|.||||...|   |...|..::
  Fly   372 VVTEPCELTNKNGVSVKLRPGDVVIIPVNALHHDPQYYEEPQSFKPERFLNINGGAKKYRDQGLF 436

Human   433 TPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ 472
            ..||.|||.|.||||:|..:|.||:.:::||..|...:|:
  Fly   437 FGFGDGPRICPGMRFSLTQIKAALVEIVRNFDIKVNPKTR 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	127/470 (27%)
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	127/470 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920