Protein Alignment CYP3A4 and Cyp28d2

DIOPT Version :9

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_608911.1
• Gene: Cyp28d2 / 33748
• FlyBaseID: FBgn0031688
• Length: 501
• Species: Drosophila melanogaster
• Alignment Length: 497
• Identity: 139/497 - (27%)
• Similarity: 239/497 - (48%)
• Gaps: 61/497 - (12%)

Human    11 TWLLLAVS-LVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSY--HKGFCMFDM-ECHKKY--- 68
            |:|:|.:: |||:|::.|.:...::|.||......||:|:..|.  .|....:|: :.::||
  Fly     6 TFLVLVLTLLVLVYVFLTWNFNYWRKRGIKTAPTWPFVGSFPSIFTRKRNIAYDIDDIYEKYKDT 70

Human    69 GKVWGFYDGQQPVLAITDPDMIKTVLVKECYSV-------FTNRR--------PFGPVGFMKSAI 118
            ..:.|.:..:.|.|.:..|:.|..:...:..|.       |.|::        ||
  Fly    71 DNMVGVFTTRVPQLLVMCPEYIHKIYATDFRSFHNNEWRNFVNKKTDMILGNNPF---------- 125

Human   119 SIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAE--TGKPVTLKDVFGAYSM 181
             :...:|||..||.:.|..:..::|.:.|:........|..:||:.:  |.:.:...|:...|:.
  Fly   126 -VLTGDEWKERRSEIMPALSPNRVKAVYPVSQSVCKKFVEYIRRQQQMATSEGLDAMDLSLCYTT 189

Human   182 DVITSTSFGVNIDSLNNPQDPFVENTKKLLR--FDFLDPFFLSITVFPFLIPILEVLNICVFPRE 244
            :|::....||:..|..:...|.::..|::..  |:|:   |.|: |......:.:..::..|.:|
  Fly   190 EVVSDCGLGVSAQSFTDTPTPLLKMIKRVFNTSFEFI---FYSV-VTNLWQKVRKFYSVPFFNKE 250

Human   245 VTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYET 309
            ...|....::|....|||..::.|.|||..|:..|..      |.|....::..::.||..|:||
  Fly   251 TEVFFLDIIRRCITLRLEKPEQQRDDFLNYMLQLQEK------KGLHTDNILINTMTFILDGFET 309

Human   310 TSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLE 374
            |:.||:.||..|..:|:.|.|:::||     ..|..|:|.:.::.:||..:.||||||...:...
  Fly   310 TALVLAHIMLMLGRNPEEQDKVRKEI-----GSADLTFDQMSELPHLDACIYETLRLFSPQVAAR 369

Human   375 RVCKKDVEI---NG--MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPY---- 430
            ::..:..|.   ||  :.:..|.||.||..|||.||:|:.:|..|.||||.:.|...:..|
  Fly   370 KLVTEPFEFANKNGRTVHLKPGDVVTIPVKALHHDPQYYEDPLTFKPERFLESNGGGMKSYRDRG 434

Human   431 IYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ 472
            :|..||.|||:|.||||||..:|.||:.:|:||..|...:|:
  Fly   435 VYLAFGDGPRHCPGMRFALTQLKAALVEILRNFEIKVNPKTR 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	128/468 (27%)
Cyp28d2	NP_608911.1	p450	38..475	CDD:299894	127/462 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920