Protein Alignment CYP3A4 and Cyp309a1

DIOPT Version :10

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_608688.3
• Gene: Cyp309a1 / 33438
• FlyBaseID: FBgn0031432
• Length: 506
• Species: Drosophila melanogaster
• Alignment Length: 506
• Identity: 129/506 - (25%)
• Similarity: 228/506 - (45%)
• Gaps: 67/506 - (13%)

Human    14 LLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGN----ILSYHKGFCMFDMECHKKYG---KV 71
            ::.|:..::|.|.|..|..:.|.|:....||..||:    :::..:...:...:.:.||.   :.
  Fly    11 IVHVAFAVVYFYLTWYHKYWDKRGVVTAEPLTILGSYPGILINKSRSLILDVQDVYNKYKDKYRT 75

Human    72 WGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVG------FMKSAISIAEDEEWKRLR 130
            .|.:..:||.|.:.||.:...:||.: :|.|.:......||      ::..:...:..::|||||
  Fly    76 VGTFITRQPQLLVLDPALAHEILVDK-FSHFRDTITSSFVGHNPDDKYVAGSPFFSAGDKWKRLR 139

Human   131 SLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRR-EAETGKPVTLKDVFGAYSMDVITSTSFGVNID 194
            |......|..:||....|..|.|..||..:.| ..|.|..:..:|:...::.:.:....:|::..
  Fly   140 SENVGGLTPSRLKMAYSIWEQSGRKLVEYIERARREQGDIIETRDLAYRFTANAMADFIWGIDAG 204

Human   195 SLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKES 259
            ||:.......:..|....:        |...|..:|...:.| :.:|.|::.: :|...|...|.
  Fly   205 SLSGKVGEIGDFQKTSTDW--------SAHAFSSMIRFNKTL-VAIFVRKLFS-MRFFTKATDEF 259

Human   260 RLEDTQ-----------KHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSV 313
            .|..||           :.|.|:|..:|..|       .:..|..:.|..::.....|:||:.:|
  Fly   260 FLRLTQDAVNLRQGGSGEGRTDYLSHLIQLQ-------QRGNSIHDSVGHALTVHLDGFETSGAV 317

Human   314 LSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRL-FPIAMRLERVC 377
            |..::|.|:.|.:.|:||:.||...|.::...:||.:..:.|||...||:||| .||...: |:|
  Fly   318 LYHMLYSLSEHHEEQEKLRSEILEALASEGQISYDQINNLPYLDQCFNESLRLTTPIGFFM-RIC 381

Human   378 KKDVEIN-----GMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF--------SKKNKDNIDP 429
            .|..:||     .:.:..||.||:|:|..|.|...:.|..:|.|:||        :|:.
  Fly   382 TKPTQINLGDDKTLDLEPGVTVMVPAYQYHHDNDIYPEASEFRPDRFENGAASVLTKRG------ 440

Human   430 YIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 480
             .:.|||.|||.|:|||...:::|.|::.:|.|:..:..|  ::||....|
  Fly   441 -CFLPFGDGPRICLGMRVGQLSVKTAIVHILSNYQVEQMK--KVPLGADSG 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	CYP3A	67..492	CDD:410743	118/449 (26%)
Cyp309a1	NP_608688.3	CYP6-like	71..480	CDD:410679	113/436 (26%)