Protein Alignment CYP3A4 and Cyp6t1

DIOPT Version :10

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_608457.1
• Gene: Cyp6t1 / 33127
• FlyBaseID: FBgn0031182
• Length: 529
• Species: Drosophila melanogaster
• Alignment Length: 505
• Identity: 138/505 - (27%)
• Similarity: 245/505 - (48%)
• Gaps: 54/505 - (10%)

Human     1 MALIPDLAMETWLLLAVSLVLLY--LYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDME 63
            :.|:| :.:....||.|::|.|:  |:..|    :::||:|.....||:||:.:..:|.|.|..:
  Fly    17 LVLLP-VVLRGGCLLVVTIVWLWQILHFWH----WRRLGVPFVPAAPFVGNVWNLLRGACCFGDQ 76

Human    64 CHKKY------GKVW-GFYDGQQPVLAITDPDMIKTVLVKECYSVFTNR-RPFGP----VGFMKS 116
            ..:.|      |:.: |........|.:.||.:||.::|:: ::.|::| ....|    :|  ..
  Fly    77 FRELYESKEAAGRAFVGIDVLHNHALLLRDPALIKRIMVED-FAQFSSRFETTDPTCDTMG--SQ 138

Human   117 AISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRRE--AETGKPVTLKDVFGAY 179
            .:..::.|.|:....:.:|.|.:||::.|..::...|..|..::.::  ......:.:|.:...:
  Fly   139 NLFFSKYETWRETHKIFAPFFAAGKVRNMYGLLENIGQKLEEHMEQKLSGRDSMELEVKQLCALF 203

Human   180 SMDVITSTSFGVNIDSLNNPQDPF----VE----NTKKLLRFDFLDPFFLSITVFPFLIPILEVL 236
            :.|:|.|.:||:...||.||:..|    :|    ..|:||..         .|:| |...:...:
  Fly   204 TTDIIASLAFGIEAHSLQNPEAEFRRMCIEVNDPRPKRLLHL---------FTMF-FFPRLSHRV 258

Human   237 NICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSII 301
            ...::..|...|:|||:..:...|.| :.::|.|.:.:.:..:.::..||.....|. ..||:..
  Fly   259 GTHLYSEEYERFMRKSMDYVLSQRAE-SGENRHDLIDIFLQLKRTEPAESIIHRPDF-FAAQAAF 321

Human   302 FIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPP--TYDTVLQMEYLDMVVNETL 364
            .:.||::|:||.::|.:||||.:..:|.:|:.|:.|.|.:....  :.|||..:.||..||:|.|
  Fly   322 LLLAGFDTSSSTITFALYELAKNTTIQDRLRTELRAALQSSQDRQLSCDTVTGLVYLRQVVDEVL 386

Human   365 RLFPIAMRLERVCKKDVEI-----NG---MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 421
            ||:|....|:|.|......     ||   ..:..|..|.|....:|||.:||..||.|.|||||.
  Fly   387 RLYPPTAFLDRCCNSRTGYDLSPWNGGSPFKLRAGTPVYISVLGIHRDAQYWPNPEVFDPERFSA 451

Human   422 KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKET 471
            :.:....|..|.|||:|||.|||.....:.:|:.|:.:|.:|..:.|:.|
  Fly   452 EQRQQHHPMTYLPFGAGPRGCIGTLLGQLEIKVGLLHILNHFRVEVCERT 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	CYP3A	67..492	CDD:410743	119/437 (27%)
Cyp6t1	NP_608457.1	CYP6-like	88..521	CDD:410679	118/429 (28%)