DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP3A4 and Cyp6v1

DIOPT Version :9

Sequence 1:	NP_059488.2	Gene:	CYP3A4 / 1576	HGNCID:	2637	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_001285499.1	Gene:	Cyp6v1 / 33056	FlyBaseID:	FBgn0031126	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	548	Identity:	183/548 - (33%)
Similarity:	275/548 - (50%)	Gaps:	90/548 - (16%)

- Green bases have known domain annotations that are detailed below.

Human     7 LAMETWLLLAVSLVL--LYLYGTHSHGLFKKLGIPGPTPLPFLGN---ILSYHKGFCM------F 60
            :...|.:|||:..:|  ::::...::..:::..:....|...|||   :|...:.|.:      |
  Fly     1 MVYSTNILLAIVTILTGVFIWSRRTYVYWQRRRVKFVQPTHLLGNLSRVLRLEESFALQLRRFYF 65

Human    61 DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMK--------SA 117
            |.....:  .|.|.|...||.|.|.|..:::||||::..| |:||       |.|        .|
  Fly    66 DERFRNE--PVVGIYLFHQPALLIRDLQLVRTVLVEDFVS-FSNR-------FAKCDGRSDKMGA 120

Human   118 IS--IAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYG-DV------LVRNLRR-EAETGKPVTL 172
            :|  :|:..||:.:|:.|:|.|...|||:|..::.:.| |:      |.|:||| :||.|..|::
  Fly   121 LSLFLAKQPEWREIRTRLAPAFAGAKLKQMFSLMEEIGCDLEWYLKRLTRDLRRGDAERGAIVSI 185

Human   173 KDVFGAYSMDVITSTSFGVNIDSLNNP--------QDPFVENTKKLLRFDFLDPFFLSITVFPFL 229
            |||...|:.|:|.|.:||:...||.|.        ||.|..|.::::  |....|:|     |.|
  Fly   186 KDVCDLYNTDMIASIAFGLRSYSLRNTQSEIGSHCQDLFRPNVRRII--DLFVIFYL-----PKL 243

Human   230 IPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMI------DSQNSKETESHK 288
            :|:|...   :|......|||:.::.:.|.| |.....|.|.:::::      |.|..|...:|.
  Fly   244 VPLLRPK---LFTEPHAEFLRRVIQLVIEER-ERGGDLRNDLIEMLLTLKKEADLQQDKSHFTHH 304

Human   289 ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEI-DAVLPN-KAPPTYDTVL 351
              .|. |.||:..|..||.||.|:.:||.:||||..|.:|.:|:.|| :|...| ....||:.|.
  Fly   305 --RDF-LAAQAASFEVAGIETCSASMSFALYELAKQPLMQSRLRREIREAFASNPNGRLTYEAVA 366

Human   352 QMEYLDMVVNETLRLFPIAMRLERVCKKDVEIN-----------GMFIPKGVVVMIPSYALHRDP 405
            :||:|||||.||||.:||...|||.|   ..||           ..:..:|:.|.|.:.|:|.||
  Fly   367 RMEFLDMVVEETLRKYPIVPLLEREC---TPINKKRFYSLRPHAECYTRRGMPVFISNLAIHHDP 428

Human   406 KYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKE 470
            |||.:|::|.|||||..||....|..|.|||:||||||||:..|:.:||.|:..|.....:.|..
  Fly   429 KYWPDPDRFDPERFSAANKALQAPMSYMPFGAGPRNCIGMQIGLLQIKLGLVYFLHQHRVEICDR 493

Human   471 T----QIPLKLSLGGLLQPEKPVVLKVE 494
            |    |...|.:   ||..|:.:.|||:
  Fly   494 TVERIQFDAKFA---LLASEQRIYLKVD 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	176/511 (34%)
Cyp6v1	NP_001285499.1	p450	59..517	CDD:299894	170/487 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8447
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920