DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP3A4 and Cyp311a1

DIOPT Version :9

Sequence 1:	NP_059488.2	Gene:	CYP3A4 / 1576	HGNCID:	2637	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster

Alignment Length:	513	Identity:	135/513 - (26%)
Similarity:	229/513 - (44%)	Gaps:	67/513 - (13%)

- Green bases have known domain annotations that are detailed below.

Human     9 METWLLLAVSLVLLYLYGTHSHGLFKKLG--IPGPTPLPFLGNILSYHK-----GFCMFDMECHK 66
            |..|.||.::|.:..|....:   ..:||  :|||...|.|||.....|     .|.:| .|...
  Fly     1 MALWPLLLITLTIWILVRKWT---LLRLGSSLPGPWAFPLLGNAQMVGKLRPEYIFLVF-TELRD 61

Human    67 KYG---------KVWGF-YDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIA 121
            ::|         ::|.| :..::...|:.||.:.|.       ..|....|.  :|   :.:.|:
  Fly    62 RFGATYRLRLGPQLWVFLHSAEETRQALHDPTLRKA-------DTFMQLEPL--IG---NGLLIS 114

Human   122 EDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITS 186
            ....|.|.|.||:|.|....|:...|.|..:.:.||..|  .|..|..:.:.:...|..:|.|..
  Fly   115 HGAHWTRQRRLLTPAFQPQLLRSFAPAIGGHVERLVGRL--GATRGAFLEVTEPLFACLLDAIVD 177

Human   187 TSFGVNIDSLNNPQDPFVEN---TKKLLRFDFLDPFFLSITVFP------FLIPILEVLNICVFP 242
            ||.|..:|:.:....|.::.   :.|||....::|...|..:|.      .|...|:|::
  Fly   178 TSMGAQLDTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLWRDLDEQLQVIH----- 237

Human   243 REVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGY 307
            .::.:.:.|..|.:.:......:.|.      ::|:....:.|. ::||..|:..:...|:|||.
  Fly   238 SQMESVIEKRAKELLDMGEPAGRAHN------LLDTLLLAKFEG-QSLSRREIRDEINTFVFAGV 295

Human   308 ETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMR 372
            :||::.:||::|.||..|:.|.:|::|:..|..::. ...|.:..:.||:.::.|.|||:.|...
  Fly   296 DTTTAAMSFVLYALAKFPETQTRLRKELQDVALDET-TDLDALNGLPYLEALIKEVLRLYTIVPT 359

Human   373 LERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDP-YIYTPFG 436
            ..|...:..||.|.....||.:.|..|.|..|.:|:.:|..|.|||:..::.....| :.|.||.
  Fly   360 TGRQTTQSTEIGGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPPAFSYIPFS 424

Human   437 SGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVE 494
            .||..|||.|::|:.|||...|:::.|..:...| |.||:|        |..:|||.:
  Fly   425 GGPHVCIGRRYSLLLMKLLTARLVREFQMELSPE-QAPLRL--------EAQMVLKAQ 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	126/478 (26%)
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	127/481 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910