Protein Alignment CYP3A4 and Cyp4d1

DIOPT Version :9

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_476907.2
• Gene: Cyp4d1 / 31188
• FlyBaseID: FBgn0005670
• Length: 512
• Species: Drosophila melanogaster
• Alignment Length: 522
• Identity: 148/522 - (28%)
• Similarity: 253/522 - (48%)
• Gaps: 57/522 - (10%)

Human    13 LLLAVSLVLLYLYGTHSHGLFKKL-----GIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVW 72
            :|.:...|.|.||    |..||:|     .:|||..||.:|:      |........|:...|::
  Fly     8 ILASALFVGLLLY----HLKFKRLIDLISYMPGPPVLPLVGH------GHHFIGKPPHEMVKKIF 62

Human    73 GF---YDGQQPVLAITDPDMIKTVLV---KECYSVFTNRRPFGPVG-------FMKSAISIAEDE 124
            .|   |...|.:.....|::  .||:   |:...|....|.....|       ::|..:.::...
  Fly    63 EFMETYSKDQVLKVWLGPEL--NVLMGNPKDVEVVLGTLRFNDKAGEYKALEPWLKEGLLVSRGR 125

Human   125 EWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRRE----AETGKPVTLKDVFGAYSMDVIT 185
            :|.:.|.:::|.|....|.:.|.:..:....|:||:.::    .::|  .:|.|.....:||.|.
  Fly   126 KWHKRRKIITPAFHFKILDQFVEVFEKGSRDLLRNMEQDRLKHGDSG--FSLYDWINLCTMDTIC 188

Human   186 STSFGVNIDSLNNPQDPFVENTKKL------LRFDFLDPFFLSITVFPFLIPILEVLNIC-VFPR 243
            .|:.||:|::.:|....:|:..|.:      ..|:.|..|.|:..:.|......:.||:. .|..
  Fly   189 ETAMGVSINAQSNADSEYVQAVKTISMVLHKRMFNILYRFDLTYMLTPLARAEKKALNVLHQFTE 253

Human   244 EVTNFLRKSVKR---MKESRLEDTQ---KHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIF 302
            ::....|:.:.|   .:||..:|..   |.::.||.:::.|     |...:.||:|::..:...|
  Fly   254 KIIVQRREELIREGSSQESSNDDADVGAKRKMAFLDILLQS-----TVDERPLSNLDIREEVDTF 313

Human   303 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN--KAPPTYDTVLQMEYLDMVVNETLR 365
            :|.|::||||.|.|..|.:||||:.|:|..|||.:|:.|  ..|.:|:.:.|:.|:|:.|.||||
  Fly   314 MFEGHDTTSSALMFFFYNIATHPEAQKKCFEEIRSVVGNDKSTPVSYELLNQLHYVDLCVKETLR 378

Human   366 LFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS-KKNKDNIDP 429
            ::|....|.|...:|.||||..||.|..:.|....|.|..:.::||..|.||||. ....:.::|
  Fly   379 MYPSVPLLGRKVLEDCEINGKLIPAGTNIGISPLYLGRREELFSEPNIFKPERFDVVTTAEKLNP 443

Human   430 YIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVE 494
            |.|.||.:|||||||.:||::.:|..:..||:::......::..|..|....:|:.::|::.||.
  Fly   444 YAYIPFSAGPRNCIGQKFAMLEIKAIVANVLRHYEVDFVGDSSEPPVLIAELILRTKEPLMFKVR 508

Human   495 SR 496
            .|
  Fly   509 ER 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	136/486 (28%)
Cyp4d1	NP_476907.2	p450	35..507	CDD:278495	136/486 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910