Protein Alignment CYP3A4 and Cyp4g1

DIOPT Version :10

• Sequence 1: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_525031.1
• Gene: Cyp4g1 / 30986
• FlyBaseID: FBgn0010019
• Length: 556
• Species: Drosophila melanogaster
• Alignment Length: 567
• Identity: 134/567 - (23%)
• Similarity: 241/567 - (42%)
• Gaps: 122/567 - (21%)

Human     9 METWLLLAVSLVLLYLYGTHSHGLFKKL-GIPGPTPLPFLG-----------NILSYHKGFCMFD 61
            |.|.|:..:..:.||.|...:...::.: .||.|..||.||           .||:...|:.
  Fly    27 MLTTLVGTLVAMALYEYWRRNSREYRMVANIPSPPELPILGQAHVAAGLSNAEILAVGLGYL--- 88

Human    62 MECHKKYGKVWGFYDGQQPVLAITDPDMIKTVL-------VKECYSVFTNRRP-FGPVGFMKSAI 118
                .|||:....:.|...::.:|:|..|:.:|       ..|.|..|   :| ||      ..:
  Fly    89 ----NKYGETMKAWLGNVLLVFLTNPSDIELILSGHQHLTKAEEYRYF---KPWFG------DGL 140

Human   119 SIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV 183
            .|:....|:..|.:::|||....||..||....:...:|..:..||  ||...:.|.....::|:
  Fly   141 LISNGHHWRHHRKMIAPTFHQSILKSFVPTFVDHSKAVVARMGLEA--GKSFDVHDYMSQTTVDI 203

Human   184 ITSTSFGVNIDSLNNPQDPFVE------------NTKKLLRFDFLDPFFLSITVFPFLIPILE-- 234
            :.||:.||......|....:.:            ..|.|.|.|         :::.| ..:.|
  Fly   204 LLSTAMGVKKLPEGNKSFEYAQAVVDMCDIIHKRQVKLLYRLD---------SIYKF-TKLREKG 258

Human   235 --VLNICVFPREVTNFLRKSVKRMKESRLEDTQ-------------------------------- 265
              ::||      :.....|.||..||:..|:::
  Fly   259 DRMMNI------ILGMTSKVVKDRKENFQEESRAIVEEISTPVASTPASKKEGLRDDLDDIDEND 317

Human   266 ---KHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDV 327
               |.|:..|..|::...:.:.|    .::.:::.:....:|.|::|||:..||.:..:..|.|:
  Fly   318 VGAKRRLALLDAMVEMAKNPDIE----WNEKDIMDEVNTIMFEGHDTTSAGSSFALCMMGIHKDI 378

Human   328 QQKLQEEIDAVLPNK--APPTYDTVLQMEYLDMVVNETLRLFP----IAMRLERVCKKDVEI-NG 385
            |.|:..|..|:..:.  ...|:...::|:||:.|:.|||||:|    ||.||:    .|::: :|
  Fly   379 QAKVFAEQKAIFGDNMLRDCTFADTMEMKYLERVILETLRLYPPVPLIARRLD----YDLKLASG 439

Human   386 MF-IPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 449
            .: :|||..|::..|.:||.|..:..|.||.|:.|..:...|...|.:.||.:|||:|:|.::|:
  Fly   440 PYTVPKGTTVIVLQYCVHRRPDIYPNPTKFDPDNFLPERMANRHYYSFIPFSAGPRSCVGRKYAM 504

Human   450 MNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 496
            :.:|:.|..:::|: .....:|:...||....:|:.|....:.:|.|
  Fly   505 LKLKVLLSTIVRNY-IVHSTDTEADFKLQADIILKLENGFNVSLEKR 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A4	NP_059488.2	CYP3A	67..492	CDD:410743	116/491 (24%)
Cyp4g1	NP_525031.1	CYP4	92..545	CDD:410721	114/488 (23%)