Protein Alignment GRK3 and Gprk1

DIOPT Version :10

• Sequence 1: NP_005151.2
• Gene: GRK3 / 157
• HGNCID: 290
• Length: 688
• Species: Homo sapiens
• Sequence 2: NP_001036438.1
• Gene: Gprk1 / 3355013
• FlyBaseID: FBgn0260798
• Length: 700
• Species: Drosophila melanogaster
• Alignment Length: 680
• Identity: 454/680 - (66%)
• Similarity: 536/680 - (78%)
• Gaps: 13/680 - (1%)

Human     1 MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFNQKIGF 65
            |||||||||||||||||||||.||||||||::.||:||:||||.|||.:..|:.|.||||:.:|:
  Fly     1 MADLEAVLADVSYLMAMEKSKCTPAARASKKLNLPDPSVRSVMYKYLEKEGELNFHKIFNEVLGY 65

Human    66 LLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSCSHPFSKQAVE 130
            |||||||.|:..|.:.|:||:|:||.:||.:..::|...:|.|||.:||:|:||.::.:||.||.
  Fly    66 LLFKDFCENDSEEPIQQLKFFEQIKLFEKTECYDERKKMARDIYDNFIMEEMLSHTYEYSKHAVA 130

Human   131 HVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNVELNIHLTMNEFSVHR 195
            .||.:|.|.:|...||:||:|||...|:|..|:||:|||||||||||||:||||.||||:|||||
  Fly   131 SVQKYLLKNEVPVDLFEPYLEEIFTQLKGKPFKKFLESDKFTRFCQWKNLELNIQLTMNDFSVHR 195

Human   196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG-DCPFIVCMTY 259
            ||||||||||||||||||||||||||||||||||||||.||||||.||..|||| ||||||||||
  Fly   196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVCMTY 260

Human   260 AFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANIL 324
            ||||||||||||||||||||||||||||:|||.||:|||.|:||||||||.|.:|||||||||||
  Fly   261 AFHTPDKLCFILDLMNGGDLHYHLSQHGIFSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANIL 325

Human   325 LDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHS 389
            |||:||.|||||||||||||||||||||||||||||||.|||:|||.|||||.||||:|||:|||
  Fly   326 LDENGHIRISDLGLACDFSKKKPHASVGTHGYMAPEVLSKGTSYDSCADWFSFGCMLYKLLKGHS 390

Human   390 PFRQHKTKDKHEIDRMTLTVNVELPDTFSPELKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFK 454
            ||||||||||.|||:||||:|||||::||.|||:|||.||||||||||||.|.|:.|||.|:||.
  Fly   391 PFRQHKTKDKLEIDKMTLTMNVELPESFSLELKNLLEMLLQRDVSKRLGCMGNGADEVKMHNFFC 455

Human   455 GVDWQHVYLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQ 519
            |:||..||:|||.|||:|||||||||||||||||||||||||||.|.||:|||.|.|.|||||||
  Fly   456 GIDWHQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEEDTKGIKLNDADQDLYKMFSLTISERWQQ 520

Human   520 EVTETVYEAVNADTDKIEARKRAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLF 584
            ||:|||::.||.:|||:|.:::.|.||  |.:......|||:|||:.|||..|.:.||.:|..|:
  Fly   521 EVSETVFDTVNTETDKLEQKRKLKQKQ--HFDADEKESDCILHGYIKKLGGSFASLWQTKYAKLY 583

Human   585 PNRLEWRGE-GESRQNLLTMEQILSVEETQI--KDKKCILFRIKGGK---QFVLQCESDPEFVQW 643
            |||||...| |.::..|:.|:|:..:....|  |::.||..||..|.   :.:|....:....:|
  Fly   584 PNRLELHSESGNNKPELIFMDQVEDISSDFILHKNENCIQIRINDGTRDGRIILTNSDEIGLKEW 648

Human   644 KKELNETFKEAQRLL----RRAPKFLNKPR 669
            ...|....|.:|.||    ::|.|.....|
  Fly   649 SSSLRSAHKISQDLLGSMAKKAGKIYGSER 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRK3	NP_005151.2	N-terminal	1..190		115/188 (61%)
		RGS_GRK2_GRK3	30..186	CDD:188701	84/155 (54%)
		STKc_GRK3	185..530	CDD:270781	291/345 (84%)
		PH_GRK2_subgroup	553..670	CDD:269946	41/127 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	669..688		1/1 (100%)
Gprk1	NP_001036438.1	RGS_GRK2_GRK3	30..186	CDD:188701	84/155 (54%)
		Protein Kinases, catalytic domain	185..531	CDD:473864	291/345 (84%)
		PH_GRK2_subgroup	552..675	CDD:269946	40/122 (33%)