Protein Alignment CYP2D6 and Cyp303a1

DIOPT Version :10

• Sequence 1: NP_000097.3
• Gene: CYP2D6 / 1565
• HGNCID: 2625
• Length: 497
• Species: Homo sapiens
• Sequence 2: NP_652070.1
• Gene: Cyp303a1 / 49165
• FlyBaseID: FBgn0001992
• Length: 503
• Species: Drosophila melanogaster
• Alignment Length: 527
• Identity: 153/527 - (29%)
• Similarity: 235/527 - (44%)
• Gaps: 71/527 - (13%)

Human    12 IVAIF-LLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFG------DVF 69
            ::.|| ..|:.::....|...|:||||...|.:|:.|.|         .|||.|.|      |||
  Fly     5 VIWIFCATLLAILFGGVRKPKRFPPGPAWYPIVGSALQV---------SQLRCRLGMFCKVIDVF 60

Human    70 S-----------LQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLAR 123
            :           |::....||:.....|:.|.:.  .||...||.....::..|..| .||.|..
  Fly    61 ARQYVNPYGFYGLKIGKDKVVIAYTNDAISEMMT--NEDIDGRPDGIFYRLRTFNSR-LGVLLTD 122

Human   124 YGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFAN----HSGRPFR--PNGLLDKAV 182
             |..|.|||||.:..|:|.|..:..:...|..||.||.....:    ..|:..|  .:.|....|
  Fly   123 -GEMWVEQRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYV 186

Human   183 SNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLL-HIPALAGKVLRF--- 243
            .|.:..:..|||:|...|...:||:...|..|.        ::.|..|. |.|     :|||
  Fly   187 LNTLWCMLSGRRYEPGSPEITQLLETFFELFKN--------IDMVGALFSHFP-----LLRFIAP 238

Human   244 -----------QKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESS-FNDENLR 296
                       .::..|.:.:.:..||:|:.....||||.:::|...:  :||.|.. |:|::|.
  Fly   239 NFSGYNGFVESHRSLYTFMSKEIELHRLTYKNYDEPRDLMDSYLRAQD--EGNDEKGMFSDQSLL 301

Human   297 IVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMG-DQAHMPYTTAVI 360
            .:..|:|.||..||:.:|.:..:.::|.|::|.|..|||.:|:|..|.||.. |:..:||..|:.
  Fly   302 AICLDMFLAGSETTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAIT 366

Human   361 HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQG 425
            .|..|...:...|:.|....|..:.|:.|||.|.:|.....:|.:...:..|..|:|:.:| ..|
  Fly   367 LEAVRMFMLHTFGIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYL-FDG 430

Human   426 HFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPY 490
            |...||||.||..||..|:|:.|.|..||:|.|::||:|......||. |....:.....:..||
  Fly   431 HLKLPEAFNPFGFGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAIPGQV-PEEVPLEGATAAVKPY 494

Human   491 ELCAVPR 497
            ::..|.|
  Fly   495 DIMLVAR 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP2D6	NP_000097.3	CYP2D	65..492	CDD:410756	134/466 (29%)
Cyp303a1	NP_652070.1	CYP15A1-like	68..496	CDD:410744	130/448 (29%)