Protein Alignment CYP2D6 and phtm

DIOPT Version :10

• Sequence 1: NP_000097.3
• Gene: CYP2D6 / 1565
• HGNCID: 2625
• Length: 497
• Species: Homo sapiens
• Sequence 2: NP_573319.1
• Gene: phtm / 32857
• FlyBaseID: FBgn0004959
• Length: 574
• Species: Drosophila melanogaster
• Alignment Length: 564
• Identity: 158/564 - (28%)
• Similarity: 239/564 - (42%)
• Gaps: 111/564 - (19%)

Human     6 LVPLAVIVAIFLLLV----DLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFG 66
            |||.|:::.|..|..    |||       ...||||..||.||.|..:|.:.......:|.:|:|
  Fly    24 LVPGALVLVILYLCERQCNDLM-------GAPPPGPWGLPFLGYLPFLDARAPHKSLQKLAKRYG 81

Human    67 DVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQIL--GFGPRSQGVFLARYGPAWR 129
            .:|.|::...|.|||:..|.||:..  ..:....|.|:.:|..:  |||      .:......||
  Fly    82 GIFELKMGRVPTVVLSDAALVRDFF--RRDVMTGRAPLYLTHGIMGGFG------IICAQEDIWR 138

Human   130 EQRRFSVSTLRNLGLGKK------SLEQWVTE-----------EAACLCAAFANHSGRPFRPNGL 177
            ..||.::..|:.||:.::      .||:.:..           ||...||:..|       |...
  Fly   139 HARRETIDWLKALGMTRRPGELRARLERRIARGVDECVRLFDTEAKKSCASEVN-------PLPA 196

Human   178 LDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLK--EESGFLREVLNAVPVLLHIPA----- 235
            |..::.|:|..|..|..::.|||.:|.|..|.:||:|  ..||    |:|.:|.|.|:||
  Fly   197 LHHSLGNIINDLVFGITYKRDDPDWLYLQRLQEEGVKLIGVSG----VVNFLPWLRHLPANVRNI 257

Human   236 ---LAGKV--------------------------LRFQKAFLTQLDELLTEHRMTWDPAQ----- 266
               |.||.                          |:.||....||::.........||:|
  Fly   258 RFLLEGKAKTHAIYDRIVEACGQRLKEKQKVFKELQEQKRLQRQLEKEQLRQSKEADPSQEQSEA 322

Human   267 -------------PPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGL 318
                         .|..:.|.|||    .:......:.|:.||.::||||.||:.|:..||.|.|
  Fly   323 DEDDEESDEEDTYEPECILEHFLA----VRDTDSQLYCDDQLRHLLADLFGAGVDTSLATLRWFL 383

Human   319 LLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIE 383
            |.:......|||: .|:...:|.  .|.:.:...:.|..|.|.|..|...:||||:.|....:..
  Fly   384 LYLAREQRCQRRL-HELLLPLGP--SPTLEELEPLAYLRACISETMRIRSVVPLGIPHGCKENFV 445

Human   384 VQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPL 448
            |..:.|..|:.::.:..::..|...:.:|..|.||.||.|.|.:..|..|:|||:|.|.|.||.:
  Fly   446 VGDYFIKGGSMIVCSEWAIHMDPVAFPEPEEFRPERFLTADGAYQAPPQFIPFSSGYRMCPGEEM 510

Human   449 ARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYEL 492
            |||.|.||...:|:.|...:|:| ......|.....::|:|:.|
  Fly   511 ARMILTLFTGRILRRFHLELPSG-TEVDMAGESGITLTPTPHML 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP2D6	NP_000097.3	CYP2D	65..492	CDD:410756	136/499 (27%)
phtm	NP_573319.1	CYP306A1-like	81..553	CDD:410745	136/498 (27%)