Protein Alignment CYP2C18 and Cyp6a19

DIOPT Version :9

• Sequence 1: NP_000763.1
• Gene: CYP2C18 / 1562
• HGNCID: 2620
• Length: 490
• Species: Homo sapiens
• Sequence 2: NP_611001.2
• Gene: Cyp6a19 / 36662
• FlyBaseID: FBgn0033979
• Length: 503
• Species: Drosophila melanogaster
• Alignment Length: 505
• Identity: 116/505 - (22%)
• Similarity: 214/505 - (42%)
• Gaps: 66/505 - (13%)

Human     4 AVALVLCLSCLFLLSLWRQSS----GRGRLPSGPTPLPIIGNILQL-----DVKDMSKSLTNFSK 59
            |:.|.|.:..|.|::.|...:    .|..:|..|..:| :||..:|     ....:.::...|.|
  Fly     2 AILLGLVVGVLTLVAWWVLQNYTYWKRRGIPHDPPNIP-LGNTGELWRTMPLAGILKRTYLKFRK 65

Human    60 -VYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSF--PVAEKVNKGLGILFSNGKRWK 121
             ..||....|......:|:...:.||..||...::|..||.:  ...:.:...|..:  .|::||
  Fly    66 QTDGPFAGFYLYAMKYIVITDVDFVKTVLIRDFDKFHDRGVYHNEKDDPLTNNLATI--EGQKWK 128

Human   122 EIRRFCLMTLRNFGMGKR-SIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVI------- 178
            .:|:....|..:..|... |....|.:|...:|:|...:::...:.|.|:.....:||
  Fly   129 NLRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISSSSQTLEVTDIVSRFTSDVIGICAFGL 193

Human   179 -CSVIFHDRFDYKDQRFLNLMEK---FNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAY 239
             |:.:...:.::....:..|.|:   :..:|.|...|.:.|...|..|:..:...:.||.
  Fly   194 KCNSLRDPKAEFVQMGYSALRERRHGWLVDLLIFGMPKLAVKLGFQFLLPSVQKFYMKIV----- 253

Human   240 IKSYVLERIKEHQESLDMNSAR-----DFIDCFL-IKMEQEKHNQQSEFTVESLIATVTDMFGAG 298
                        |:::|....|     ||:|..: :|.:.:|.::::......:.|.....|.||
  Fly   254 ------------QDTIDYRMKRKVTRNDFMDTLIDMKQQYDKGDKENGLAFNEVAAQAFVFFLAG 306

Human   299 TETTSTTLRYGLLLLLKYPEVTAKVQEEIECVV----GRNRSPCMQDRSHMPYTDAVVHEIQRYI 359
            .|..|||:.:.|..|....:|..|::.||:.|:    |:.....|||   :.|.:.|::|..|..
  Fly   307 FEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYNGKLEYDSMQD---LFYMEKVINESLRKH 368

Human   360 DLLPTNLPHAVTCDVKFKN--YLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKS 422
            .:: .:|....|...:..|  |.|..||.::.|...:.|:.:.:|.||.|.|..|.::....:.:
  Fly   369 PVV-AHLARIATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFDEEQVKKRPT 432

Human   423 DYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPI 472
            ..|:||.||.|.|:|....||::.:.|..::.||  :.::.||    ||:
  Fly   433 CAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNF--RFELHPK----TPV 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP2C18	NP_000763.1	p450	30..487	CDD:306555	109/475 (23%)
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	109/475 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4116
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950