DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GRK2 and TPK2

DIOPT Version :9

Sequence 1:	NP_001610.2	Gene:	GRK2 / 156	HGNCID:	289	Length:	689	Species:	Homo sapiens
Sequence 2:	NP_015121.1	Gene:	TPK2 / 855898	SGDID:	S000006124	Length:	380	Species:	Saccharomyces cerevisiae

Alignment Length:	334	Identity:	115/334 - (34%)
Similarity:	184/334 - (55%)	Gaps:	30/334 - (8%)

- Green bases have known domain annotations that are detailed below.

Human   187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKR-IKMKQGETLALNERIMLSLVSTGD 250
            |::||.:.|.:|.|.||.|:..|....|:.||:|.|.|:: :||||.|. ..:||.||.||   :
Yeast    66 TLHDFQIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMKQVEH-TNDERRMLKLV---E 126

Human   251 CPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVY 315
            .||::.|...|.....:..::|.:.||:|...|.:...|.....:|||||:||.||::|...::|
Yeast   127 HPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVILALEYLHAHNIIY 191

Human   316 RDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS---VGTHGYMAPEVLQKGVAYDSSADWFSL 377
            |||||.|||||.:||::|:|.|    |:|:....:   .||..|:||||:.. ..|:.|.||:||
Yeast   192 RDLKPENILLDRNGHIKITDFG----FAKEVQTVTWTLCGTPDYIAPEVITT-KPYNKSVDWWSL 251

Human   378 GCMLFKLLRGHSPF---RQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGC 439
            |.:::::|.|::||   ...||.:|      .|...|..|..|.|::..||..|:..|:.||:|.
Yeast   252 GVLIYEMLAGYTPFYDTTPMKTYEK------ILQGKVVYPPYFHPDVVDLLSKLITADLTRRIGN 310

Human   440 LGRGAQEVKESPFFRSLDWQMVFLQ----KYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLD 500
            |..|::::|..|:|..:.|:.:..:    .|.||:....|:.:..|.:.    :|:...||:..|
Yeast   311 LQSGSRDIKAHPWFSEVVWERLLAKDIETPYEPPITSGIGDTSLFDQYP----EEQLDYGIQGDD 371

Human   501 SDQELYRNF 509
            ...|.:::|
Yeast   372 PYAEYFQDF 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GRK2	NP_001610.2	N-terminal	1..190		1/2 (50%)
		RGS_GRK2_GRK3	30..186	CDD:188701
		STKc_GRK2	190..510	CDD:271125	114/331 (34%)
		PH_GRK2_subgroup	553..670	CDD:269946
TPK2	NP_015121.1	STKc_PKA_like	69..358	CDD:270732	108/303 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910