Protein Alignment GRK2 and YPK2

DIOPT Version :9

• Sequence 1: NP_001610.2
• Gene: GRK2 / 156
• HGNCID: 289
• Length: 689
• Species: Homo sapiens
• Sequence 2: NP_013822.1
• Gene: YPK2 / 855130
• SGDID: S000004710
• Length: 677
• Species: Saccharomyces cerevisiae
• Alignment Length: 584
• Identity: 168/584 - (28%)
• Similarity: 255/584 - (43%)
• Gaps: 145/584 - (24%)

Human    18 EKSKATPAARASKKILLPEP--SIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLNHLEEAR 80
            |....|....:.|...||.|  |..:::||.|.. |.:|                   :...:|.
Yeast   113 ESGLMTVKVYSGKDFTLPFPITSNSTILQKLLSS-GILT-------------------SSSNDAS 157

Human    81 PLVEFYEEIKKYEKLETEE------ERVARSREIFDSYIM------KELLACSHPFSKSATEHVQ 133
            .:.....::.:|::::.:.      :|...::.|..|.::      ..||..:..|..|.|
Yeast   158 EVAAIMRQLPRYKRVDQDSAGEGLIDRAFATKFIPSSILLPGSTNSSPLLYFTIEFDNSIT---- 218

Human   134 GHLGKKQVPPD---LFQPYIEEICQNLRGDVFQK--FIESDKFTRF-------CQWK-------- 178
                  .:.||   :.||...:|.   ..||.:|  |::.|.|.|.       ..|:
Yeast   219 ------TISPDMGTMEQPVFNKIS---TFDVTRKLRFLKIDVFARIPSLLLPSKNWQQEIGEQDE 274

Human   179 ---------NVELNIH------------------------------------------------L 186
                     |...:||                                                |
Yeast   275 VLKEILKKINTNQDIHLDSFHLPLNLKIDSAAQIRLYNHHWISLERGYGKLNITVDYKPSKNKPL 339

Human   187 TMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDC 251
            :::||.:.::||:|.||:|...||.||.|:||:|.|.|..|..|...|..|.||.:|:.|   ||
Yeast   340 SIDDFDLLKVIGKGSFGKVMQVRKKDTQKIYALKALRKAYIVSKCEVTHTLAERTVLARV---DC 401

Human   252 PFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYR 316
            ||||.:.::|.:|:||..:|..:|||:|.|||...|.||.|..|||.||::..|:.:|...|:||
Yeast   402 PFIVPLKFSFQSPEKLYLVLAFINGGELFYHLQHEGRFSLARSRFYIAELLCALDSLHKLDVIYR 466

Human   317 DLKPANILLDEHGHVRISDLGLACDFSKK---KPHASVGTHGYMAPEVLQKGVAYDSSADWFSLG 378
            ||||.|||||..||:.:.|.|| |..:.|   |.....||..|:|||:| .|..|..:.||::||
Yeast   467 DLKPENILLDYQGHIALCDFGL-CKLNMKDNDKTDTFCGTPEYLAPEIL-LGQGYTKTVDWWTLG 529

Human   379 CMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRG 443
            .:|::::.|..|:........:   :..|...:..||.|.|..:.||.|||.||.:||||.  .|
Yeast   530 ILLYEMMTGLPPYYDENVPVMY---KKILQQPLLFPDGFDPAAKDLLIGLLSRDPSRRLGV--NG 589

Human   444 AQEVKESPFFRSLDWQMVFLQKYPPPLIP-PRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELY 506
            ..|::..|||:.:.|:.:.|:.|.||..| .:.|:      |..:||:|.||. |.:||..:.|
Yeast   590 TDEIRNHPFFKDISWKKLLLKGYIPPYKPIVKSEI------DTANFDQEFTKE-KPIDSVVDEY 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRK2	NP_001610.2	N-terminal	1..190		39/262 (15%)
		RGS_GRK2_GRK3	30..186	CDD:188701	36/246 (15%)
		STKc_GRK2	190..510	CDD:271125	129/321 (40%)
		PH_GRK2_subgroup	553..670	CDD:269946
YPK2	NP_013822.1	YPK1_N_like	114..339	CDD:212165	37/257 (14%)
		PKc_like	349..660	CDD:419665	127/315 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910