Protein Alignment GRK2 and MPS1

DIOPT Version :9

• Sequence 1: NP_001610.2
• Gene: GRK2 / 156
• HGNCID: 289
• Length: 689
• Species: Homo sapiens
• Sequence 2: NP_010256.2
• Gene: MPS1 / 851533
• SGDID: S000002186
• Length: 764
• Species: Saccharomyces cerevisiae
• Alignment Length: 430
• Identity: 98/430 - (22%)
• Similarity: 174/430 - (40%)
• Gaps: 105/430 - (24%)

Human    81 PLVEFYEEIKKYEKLETEEERVARSREI----FDSYIMKELLACSHPFSKSATEHVQGHLGKKQV 141
            |:.:.|:.|.:.:..::|:..|.|:..|    .|:.:.:|..........:.|..   ::..|.:
Yeast   337 PIHKIYKGISRNKDSDSEKREVLRNISINANHADNLLQQENKRLKRSLDDAITNE---NINSKNL 398

Human   142 P-----PDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRI--IGR 199
            .     |....|..:::          :.:|..|.......:|:     :|:||....:|  :||
Yeast   399 EVFYHRPAPKPPVTKKV----------EIVEPAKSASLSNNRNI-----ITVNDSQYEKIELLGR 448

Human   200 GGFGEVYGCRKADTGKMYAMK-----CLDKKRIKMKQGETLALNER-------IMLSLVSTGDCP 252
            ||...||.. |....::||:|     ..|...|...:|| :.|.|:       |.|.....||..
Yeast   449 GGSSRVYKV-KGSGNRVYALKRVSFDAFDDSSIDGFKGE-IELLEKLKDQKRVIQLLDYEMGDGL 511

Human   253 FIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRD 317
            ..:.|....|   .||.||:..:|..|.::.          :|||..|::|.::.:|:..:|:.|
Yeast   512 LYLIMECGDH---DLSQILNQRSGMPLDFNF----------VRFYTKEMLLCIKVVHDAGIVHSD 563

Human   318 LKPANILLDEHGHVRISDLGLACDFSKKKPH-------ASVGTHGYMAPEVLQKGVAYDSS---- 371
            |||||.:|.: |.::|.|.|:|   :....|       ..:||..|||||.|   ||.:.:
Yeast   564 LKPANFVLVK-GILKIIDFGIA---NAVPEHTVNIYRETQIGTPNYMAPEAL---VAMNYTQNSE 621

Human   372 -------------ADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPD---SFSPE 420
                         :|.:|.||::::::.|..|:...:.:::        .:|:..||   .| ||
Yeast   622 NQHEGNKWKVGRPSDMWSCGCIIYQMIYGKPPYGSFQGQNR--------LLAIMNPDVKIPF-PE 677

Human   421 LRSLLEGLLQRDVNRRLGCLGRG------AQEVKESPFFR 454
            ..|..|.:.:..:.....||.|.      ..:|..|.|.:
Yeast   678 HTSNNEKIPKSAIELMKACLYRNPDKRWTVDKVLSSTFLQ 717

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GRK2	NP_001610.2	N-terminal	1..190		17/117 (15%)
		RGS_GRK2_GRK3	30..186	CDD:188701	16/113 (14%)
		STKc_GRK2	190..510	CDD:271125	80/312 (26%)
		PH_GRK2_subgroup	553..670	CDD:269946
MPS1	NP_010256.2	PKc_Mps1	439..716	CDD:271033	78/307 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910