DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GRK2 and Gprk1

DIOPT Version :9

Sequence 1:	NP_001610.2	Gene:	GRK2 / 156	HGNCID:	289	Length:	689	Species:	Homo sapiens
Sequence 2:	NP_001036438.1	Gene:	Gprk1 / 3355013	FlyBaseID:	FBgn0260798	Length:	700	Species:	Drosophila melanogaster

Alignment Length:	674	Identity:	452/674 - (67%)
Similarity:	538/674 - (79%)	Gaps:	9/674 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGY 65
            |||||||||||||||||||||.|||||||||:.||:||:||||.||||..||:.|.|||::.|||
  Fly     1 MADLEAVLADVSYLMAMEKSKCTPAARASKKLNLPDPSVRSVMYKYLEKEGELNFHKIFNEVLGY 65

Human    66 LLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLACSHPFSKSATE 130
            |||:|||.|..||....::|:|:||.:||.|..:||...:|:|:|::||:|:|:.::.:||.|..
  Fly    66 LLFKDFCENDSEEPIQQLKFFEQIKLFEKTECYDERKKMARDIYDNFIMEEMLSHTYEYSKHAVA 130

Human   131 HVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHR 195
            .||.:|.|.:||.|||:||:|||...|:|..|:||:|||||||||||||:||||.||||||||||
  Fly   131 SVQKYLLKNEVPVDLFEPYLEEIFTQLKGKPFKKFLESDKFTRFCQWKNLELNIQLTMNDFSVHR 195

Human   196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTG-DCPFIVCMSY 259
            ||||||||||||||||||||||||||||||||||||||.||||||.||..|||| ||||||||:|
  Fly   196 IIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGEMLALNERNMLQAVSTGIDCPFIVCMTY 260

Human   260 AFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANIL 324
            ||||||||.|||||||||||||||||||:|||.:|:|||||:||||||||.|.:|||||||||||
  Fly   261 AFHTPDKLCFILDLMNGGDLHYHLSQHGIFSEDEMKFYAAEVILGLEHMHKRCIVYRDLKPANIL 325

Human   325 LDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHS 389
            |||:||:|||||||||||||||||||||||||||||||.||.:|||.|||||.||||:|||:|||
  Fly   326 LDENGHIRISDLGLACDFSKKKPHASVGTHGYMAPEVLSKGTSYDSCADWFSFGCMLYKLLKGHS 390

Human   390 PFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFR 454
            ||||||||||.|||:|||||.||||:|||.||::|||.||||||::||||:|.||.|||...||.
  Fly   391 PFRQHKTKDKLEIDKMTLTMNVELPESFSLELKNLLEMLLQRDVSKRLGCMGNGADEVKMHNFFC 455

Human   455 SLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQ 519
            .:||..|::|||.|||:|||||||||||||||||||||||||||.|:||:||:.|.|||||||||
  Fly   456 GIDWHQVYIQKYTPPLVPPRGEVNAADAFDIGSFDEEDTKGIKLNDADQDLYKMFSLTISERWQQ 520

Human   520 EVAETVFDTINAETDRLEARKKAKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLF 584
            ||:||||||:|.|||:||.::|.|.||  |.:......|||:|||:.|:|..|.:.||.:|..|:
  Fly   521 EVSETVFDTVNTETDKLEQKRKLKQKQ--HFDADEKESDCILHGYIKKLGGSFASLWQTKYAKLY 583

Human   585 PNRLEWRGE-GEAPQSLLTMEEIQSVEETQI--KERKCLLLKIRGGK---QFILQCDSDPELVQW 643
            |||||...| |.....|:.|::::.:....|  |...|:.::|..|.   :.||....:..|.:|
  Fly   584 PNRLELHSESGNNKPELIFMDQVEDISSDFILHKNENCIQIRINDGTRDGRIILTNSDEIGLKEW 648

Human   644 KKELRDAYREAQQLVQRVPKMKNK 667
            ...||.|::.:|.|:..:.|...|
  Fly   649 SSSLRSAHKISQDLLGSMAKKAGK 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GRK2	NP_001610.2	N-terminal	1..190		118/188 (63%)
		RGS_GRK2_GRK3	30..186	CDD:188701	87/155 (56%)
		STKc_GRK2	190..510	CDD:271125	266/320 (83%)
		PH_GRK2_subgroup	553..670	CDD:269946	38/121 (31%)
Gprk1	NP_001036438.1	RGS_GRK2_GRK3	30..186	CDD:188701	87/155 (56%)
		PKc_like	185..531	CDD:304357	288/345 (83%)
		Pkinase	191..454	CDD:278497	222/262 (85%)
		PH_GRK2_subgroup	552..675	CDD:269946	38/121 (31%)
		PH	559..657	CDD:278594	32/97 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154960
Domainoid	1	1.000	476	1.000	Domainoid score	I439
eggNOG	1	0.900	-	-		E1_KOG0986
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	915	1.000	Inparanoid score	I362
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45729
OrthoDB	1	1.010	-	-		D1104340at2759
OrthoFinder	1	1.000	-	-		FOG0004399
OrthoInspector	1	1.000	-	-		otm40682
orthoMCL	1	0.900	-	-		OOG6_106250
Panther	1	1.100	-	-	O	PTHR24355
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2554
SonicParanoid	1	1.000	-	-		X3114
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800