Protein Alignment CYP2C8 and Cyp303a1

DIOPT Version :9

• Sequence 1: NP_000761.3
• Gene: CYP2C8 / 1558
• HGNCID: 2622
• Length: 490
• Species: Homo sapiens
• Sequence 2: NP_001285977.1
• Gene: Cyp303a1 / 49165
• FlyBaseID: FBgn0001992
• Length: 503
• Species: Drosophila melanogaster
• Alignment Length: 484
• Identity: 136/484 - (28%)
• Similarity: 254/484 - (52%)
• Gaps: 41/484 - (8%)

Human     5 VVLVLCLSFM-LLFSLWRQSCRRRKLPPGPTPLPIIGNMLQID-----VKDICKSFTNFSKVYGP 63
            |:.:.|.:.: :||...|   :.::.||||...||:|:.||:.     :...||....|::.|..
  Fly     5 VIWIFCATLLAILFGGVR---KPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVN 66

Human    64 VFTVY---FGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRI---TKGLGIISSNGKRWKE 122
            .:..|   .|.:.:|:.:..:|:.|.:  ..|:..||.:. |..|:   ...||::.::|:.|.|
  Fly    67 PYGFYGLKIGKDKVVIAYTNDAISEMM--TNEDIDGRPDG-IFYRLRTFNSRLGVLLTDGEMWVE 128

Human   123 IRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEEL---------RKTKASPCDPT--FILGCAPCN 176
            .|||.|..|:|||..:..:.|.|..||.||:::|         ::|:....|.|  ::|     |
  Fly   129 QRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVL-----N 188

Human   177 VICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFP--GTHNKVLKNVAL 239
            .:..::..:|::........|::.|.|.|:.::... .:.::||||....|  ..:|..:::...
  Fly   189 TLWCMLSGRRYEPGSPEITQLLETFFELFKNIDMVG-ALFSHFPLLRFIAPNFSGYNGFVESHRS 252

Human   240 TRSYIREKVKEHQASL-DVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTS 303
            ..:::.::::.|:.:. :.:.|||.:|.:| :.:.|.:::|..|:.::|:....|:|:||:|||:
  Fly   253 LYTFMSKEIELHRLTYKNYDEPRDLMDSYL-RAQDEGNDEKGMFSDQSLLAICLDMFLAGSETTN 316

Human   304 TTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSP-CMQDRSHMPYTDAVVHEIQRYSDLVPTGVP 367
            .:|.:..:.|:..||:..:..:||..|:|..|.| ..:||:.:||.:|:..|..|...|...|:|
  Fly   317 KSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEAVRMFMLHTFGIP 381

Human   368 HAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGK 432
            |....||:...|.|||.|.::|....:|.:..:||:|..|:|..:| .:|:.|..:.|.||..|:
  Fly   382 HRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYL-FDGHLKLPEAFNPFGFGR 445

Human   433 RICAGEGLARMELFLFLTTILQNFNLKSV 461
            ..|.|:.|.|..||:|.||:||||.:.::
  Fly   446 HRCMGDLLGRQNLFMFTTTVLQNFKMVAI 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP2C8	NP_000761.3	p450	30..487	CDD:278495	131/458 (29%)
Cyp303a1	NP_001285977.1	p450	28..480	CDD:278495	131/458 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920