DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CYP2C8 and spo

DIOPT Version :9

Sequence 1:	NP_000761.3	Gene:	CYP2C8 / 1558	HGNCID:	2622	Length:	490	Species:	Homo sapiens
Sequence 2:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	514	Identity:	148/514 - (28%)
Similarity:	235/514 - (45%)	Gaps:	96/514 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    31 PGPTPLPIIGNMLQID-VKDI-CKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEE 93
            |||.|.|||||:..:| .:|. ...||..::.||.::::.||....:|.:..|.::|.|..||:.
  Fly    56 PGPRPWPIIGNLHLLDRYRDSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKV 120

Human    94 FSGRGNSPISQRITKGLGIISSNGKR---WKEI--------------RRFSLTTLRNFGMGKRSI 141
            .|||   |...|..|..|...||...   |.::              |.||...::...:|...:
  Fly   121 MSGR---PDFIRYHKLFGGERSNSLALCDWSQLQQKRRNLARRHCSPREFSCFYMKMSQIGCEEM 182

Human   142 EDRVQEEAHCLVEELRKTKASPCD--PTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNEN 204
            |...:|..:.||      ...|.:  |..:..||  |:....:...||||.|.:|..:::.|:|.
  Fly   183 EHWNRELGNQLV------PGEPINIKPLILKACA--NMFSQYMCSLRFDYDDVDFQQIVQYFDEI 239

Human   205 FRILNS-------PWIQVCNNFPLLIDCFPGTH-NKVLKNVALTRSYIREKVKEH-QASLDVNNP 260
            |..:|.       ||:     :|     |...| ||::...:..|.:|.|::..| :.|:|::.|
  Fly   240 FWEINQGHPLDFLPWL-----YP-----FYQRHLNKIINWSSTIRGFIMERIIRHRELSVDLDEP 294

Human   261 -RDFIDCFLIKMEQEKDNQKSE--FNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAK 322
             |||.|..|..:.::||..::.  |.:|:        |:.|.......:...|..:.|:.::..:
  Fly   295 DRDFTDALLKSLLEDKDVSRNTIIFMLED--------FIGGHSAVGNLVMLVLAYIAKNVDIGRR 351

Human   323 VQEEIDHVI-GRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTT 386
            :|||||.:| ..:||..:.|.:.||||.|.:.|:.|||. .|. |||..|.||....|.:.|| |
  Fly   352 IQEEIDAIIEEENRSINLLDMNAMPYTMATIFEVLRYSS-SPI-VPHVATEDTVISGYGVTKG-T 413

Human   387 IMALLTSVLHDDKEF-PNPNIFDPGHFLDKN-----GNFKKSD-----------------YFMPF 428
            |:.:...||:..::| .||..|:|..||:.:     .|.|.||                 :|:||
  Fly   414 IVFINNYVLNTSEKFWVNPKEFNPLRFLEPSKEQSPKNSKGSDSGIESDNEKLQLKRNIPHFLPF 478

Human   429 SAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICF 487
            |.|||.|.|:.|.|...||.:..::|.:|:.|    .|.:|..::...::||..   ||
  Fly   479 SIGKRTCIGQNLVRGFGFLVVVNVMQRYNISS----HNPSTIKISPESLALPAD---CF 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP2C8	NP_000761.3	p450	30..487	CDD:278495	146/512 (29%)
spo	NP_001286943.1	p450	56..540	CDD:299894	148/514 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920