Protein Alignment CYP2C8 and Cyp6a19

DIOPT Version :9

• Sequence 1: NP_000761.3
• Gene: CYP2C8 / 1558
• HGNCID: 2622
• Length: 490
• Species: Homo sapiens
• Sequence 2: NP_611001.2
• Gene: Cyp6a19 / 36662
• FlyBaseID: FBgn0033979
• Length: 503
• Species: Drosophila melanogaster
• Alignment Length: 498
• Identity: 118/498 - (23%)
• Similarity: 209/498 - (41%)
• Gaps: 74/498 - (14%)

Human     5 VVLVLCLSFMLLFSLW----RQSCRRRKLPPGPTPLPIIGNMLQI----DVKDICK-SFTNFSK- 59
            ::|.|.:..:.|.:.|    ....:||.:|..|..:| :||..::    .:..|.| ::..|.|
  Fly     3 ILLGLVVGVLTLVAWWVLQNYTYWKRRGIPHDPPNIP-LGNTGELWRTMPLAGILKRTYLKFRKQ 66

Human    60 VYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRG--NSPISQRITKGLGIISSNGKRWKE 122
            ..||....|......:|....:.||..||.:.::|..||  ::.....:|..|..|  .|::||.
  Fly    67 TDGPFAGFYLYAMKYIVITDVDFVKTVLIRDFDKFHDRGVYHNEKDDPLTNNLATI--EGQKWKN 129

Human   123 IR------------RFSLTTLRNFGMGK-RSIEDRVQEEAHCL-VEELRKTKASPCDPTFILGCA 173
            :|            :...:|:.|.|... |.:::::...:..| |.::.....|.     ::|..
  Fly   130 LRQKLTHTFTSAKMKSMFSTVLNVGDEMIRVVDEKISSSSQTLEVTDIVSRFTSD-----VIGIC 189

Human   174 PCNVICSVVFQKRFDYKDQNFLTLMKR---FNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLK 235
            ...:.|:.:...:.::....:..|.:|   :..:..|...|.:.|...|..|:   |......:|
  Fly   190 AFGLKCNSLRDPKAEFVQMGYSALRERRHGWLVDLLIFGMPKLAVKLGFQFLL---PSVQKFYMK 251

Human   236 NVALTRSY-IREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSE----FNIENLVGTVADLF 295
            .|..|..| ::.||..:          ||:|. ||.|:|:.|....|    ||  .:.......|
  Fly   252 IVQDTIDYRMKRKVTRN----------DFMDT-LIDMKQQYDKGDKENGLAFN--EVAAQAFVFF 303

Human   296 VAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRS----PCMQDRSHMPYTDAVVHEIQ 356
            :||.|..|||:.:.|..|..:.:|..|::.|||.|:.|:..    ..|||   :.|.:.|::|..
  Fly   304 LAGFEAGSTTMGFTLYELACNQDVQDKLRAEIDSVLERYNGKLEYDSMQD---LFYMEKVINESL 365

Human   357 RYSDLVPTGVPHAVTTDTK-FRN----YLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKN 416
            |...:    |.|.....|| :::    |.|..||.::.....:.||.:.:|.|..|.|..|.::.
  Fly   366 RKHPV----VAHLARIATKPYQHSNPKYFIEAGTGVLVSTLGIHHDPEFYPEPEKFIPERFDEEQ 426

Human   417 GNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLK 459
            ...:.:..|:||.||.|.|.|....||::.:.|..::.||..:
  Fly   427 VKKRPTCAFLPFGAGPRNCIGLRFGRMQVIIGLALLIHNFRFE 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP2C8	NP_000761.3	p450	30..487	CDD:278495	112/469 (24%)
Cyp6a19	NP_611001.2	p450	32..495	CDD:278495	112/469 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4116
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950