Protein Alignment CYP2C19 and Cyp303a1

DIOPT Version :10

• Sequence 1: NP_000760.1
• Gene: CYP2C19 / 1557
• HGNCID: 2621
• Length: 490
• Species: Homo sapiens
• Sequence 2: NP_652070.1
• Gene: Cyp303a1 / 49165
• FlyBaseID: FBgn0001992
• Length: 503
• Species: Drosophila melanogaster
• Alignment Length: 518
• Identity: 145/518 - (27%)
• Similarity: 253/518 - (48%)
• Gaps: 71/518 - (13%)

Human     8 VLCLSCLLLLSIWRQSSGRGK-LPPGPTPLPVIGNILQID-----------IKDV-SKSLTNLSK 59
            |:.:.|..||:|......:.| .||||...|::|:.||:.           :.|| ::...|...
  Fly     5 VIWIFCATLLAILFGGVRKPKRFPPGPAWYPIVGSALQVSQLRCRLGMFCKVIDVFARQYVNPYG 69

Human    60 IYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGR--GHFPLAERANRGFGIVFSNGKRWKE 122
            .||    |..|.:::|:.:..:.:.|.:.:  |:..||  |.|......|...|::.::|:.|.|
  Fly    70 FYG----LKIGKDKVVIAYTNDAISEMMTN--EDIDGRPDGIFYRLRTFNSRLGVLLTDGEMWVE 128

Human   123 IRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEEL---------RKTKASPCDPT--FILGCAPCN 176
            .|||.|..|:|||..:..:.|.|..||.||:::|         ::|:....|.|  ::|     |
  Fly   129 QRRFILRHLKNFGFARSGMMDIVHNEATCLLQDLKDKVLKSGGKQTRIEMHDLTSVYVL-----N 188

Human   177 VICSIIFQKRFDYKDQQFLNLME---KLNENIRIVSTPWIQICNNFPT---IIDYFPG------T 229
            .:..::..:|::....:...|:|   :|.:||.:|..    :.::||.   |...|.|      :
  Fly   189 TLWCMLSGRRYEPGSPEITQLLETFFELFKNIDMVGA----LFSHFPLLRFIAPNFSGYNGFVES 249

Human   230 HNKLLKNLAFMESDI-LEKV--KEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITA 291
            |..|   ..||..:| |.::  |.:.|      |||.:|.:| :.:.|..:::..|:.::|:...
  Fly   250 HRSL---YTFMSKEIELHRLTYKNYDE------PRDLMDSYL-RAQDEGNDEKGMFSDQSLLAIC 304

Human   292 ADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSP-CMQDRGHMPYTDAVVHEV 355
            .|:..||:|||:.:|.:..:.|:..||:..:..:||:.|:|..|.| ..:||..:||.:|:..|.
  Fly   305 LDMFLAGSETTNKSLGFCFMHLVLQPEIQERAFQEIKEVVGLERIPEWSRDRTKLPYCEAITLEA 369

Human   356 QRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK 420
            .|...|....:||...||.:...|.|||.|.::.....:|.:..:||:||.|:|..:|.: |:.|
  Fly   370 VRMFMLHTFGIPHRAVCDTRLSGYEIPKDTMVIACFRGMLINPVDFPDPESFNPDRYLFD-GHLK 433

Human   421 KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDL-DTTPVVNGFASVPPF 482
            ....|.||..|:..|:|:.|.|..||:|.|.:||||.:.::  |..: :..|:....|:|.|:
  Fly   434 LPEAFNPFGFGRHRCMGDLLGRQNLFMFTTTVLQNFKMVAI--PGQVPEEVPLEGATAAVKPY 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP2C19	NP_000760.1	CYP2C-like	61..485	CDD:410758	128/452 (28%)
Cyp303a1	NP_652070.1	CYP15A1-like	68..496	CDD:410744	128/455 (28%)