Protein Alignment Slc6a4 and GlyT

DIOPT Version :9

• Sequence 1: NP_034614.2
• Gene: Slc6a4 / 15567
• MGIID: 96285
• Length: 630
• Species: Mus musculus
• Sequence 2: NP_611836.2
• Gene: GlyT / 37772
• FlyBaseID: FBgn0034911
• Length: 1188
• Species: Drosophila melanogaster
• Alignment Length: 640
• Identity: 252/640 - (39%)
• Similarity: 381/640 - (59%)
• Gaps: 58/640 - (9%)

Mouse    30 GVPTPADKAGPGQISNGYSAV-PSTSAGDEAPHSTPAATTTLV-----------AEIHQGERETW 82
            |..:.:..||.|.:..|...| |||:.      |..|:.|.|:           |...:.||.||
  Fly     2 GQSSKSGSAGVGGVGGGGGVVCPSTAI------SGCASGTALIQLDATGPGAGGAGESEHERGTW 60

Mouse    83 GKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGC 147
            ..:.|||||::||:|.|||:|||||:||.|||||||:|:|||.:..|:||.:|||:.|||...|.
  Fly    61 TGRFDFLLSLLGYSVGLGNVWRFPYLCYNNGGGAFLIPFTIMLVIAGLPLMFMELSFGQYAALGP 125

Mouse   148 ISIWKKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSFTDQLPWTSCKNSWNTGNCTNY 212
            ::::::.||:|:|:|..:.:::..:..|||.||||.::|:.:||...|||.:|:.:|:|..|.:|
  Fly   126 VAVYRRFCPLFRGLGTGMILVSAIVMLYYNLIIAWTIFYMFASFAPVLPWQNCEPAWSTKYCFSY 190

Mouse   213 FAQD-----NITW---TLHSTS------------------PAEEFYLRHVLQIHQSKGLQDLGTI 251
            ...|     |.|:   |.|:.:                  ||||::...||.:  |||:::.|:|
  Fly   191 AQADQCEATNGTYYLRTCHNATSAAENNITTLALGALKRPPAEEYFNNFVLGL--SKGIEETGSI 253

Mouse   252 SWQLALCIMLIFTIIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPN 316
            ...||.|:.|.:||::..:.|||::|||||:.||.|||:||.:|.|||.|||||..|::|||.|:
  Fly   254 KLSLAACLFLAWTIVFLCLCKGVQSSGKVVYFTALFPYVVLVILFVRGVTLPGASTGILFYLTPD 318

Mouse   317 WQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFT 381
            |::|....||.|||.||||:|.|.:|.|:..:|||||:||||:|:|:.:..|..|||.:|.|||:
  Fly   319 WKQLANAQVWGDAAVQIFFALSPAWGGLITLSSYNKFSNNCYKDSLIVAFCNIATSFFAGLVIFS 383

Mouse   382 VLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGV 446
            ::|::|...|.||.:|. |.|..|.||.|.|.:..:|.|..:|::||:||:||||||.||.:|.|
  Fly   384 IIGFLAHELNVDVEKVV-DQGAGLAFIVYPEVVTRLPVSPVWAVLFFVMLLTLGLDSQFALMETV 447

Mouse   447 ITAVLDEFPHIWAKRREWFVLIVVITCILGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVV 511
            .||:||.||:: .:.:.|.||.|.|...:|.|...|:.|.|.:.|:::||...:||.:|:.|.::
  Fly   448 TTAILDRFPNL-RQYKIWVVLSVAIFGYIGGLGFTTNSGMYWLQLMDKYAANWSVLLIAISECIL 511

Mouse   512 VSWFYGITQFCSDVKEMLGFSPGWFWR----ICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPH 572
            ::|.||..:|.:|::.|:| ...|||.    |.|..|:|..||||:....:.....:...|.||.
  Fly   512 IAWIYGSQRFLNDIQGMIG-KRSWFWNFFWGIMWRYITPATLLFILFFNWVEYKPAKYGHYVYPM 575

Mouse   573 WSIILGYCIGTSSVICIPIYIIYRLISTPGTL--KERIIKSITPET---PTEIPC 622
            |:..:|:.:|...|:.|.:.....:...|.:|  ::||...:.|..   |...||
  Fly   576 WADAVGWIVGLLPVLVIFLVAFQEIWRAPMSLSFRDRIKHLLQPTAEWGPAGRPC 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slc6a4	NP_034614.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63		9/33 (27%)
		5HT_transport_N	24..64	CDD:281488	10/34 (29%)
		SLC6sbd_SERT	79..615	CDD:271399	233/567 (41%)
		Interaction with RAB4A. /evidence=ECO:0000250	616..624		3/10 (30%)
GlyT	NP_611836.2	SNF	57..603	CDD:249680	229/550 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820