Protein Alignment Slc6a4 and ine

DIOPT Version :9

• Sequence 1: NP_034614.2
• Gene: Slc6a4 / 15567
• MGIID: 96285
• Length: 630
• Species: Mus musculus
• Sequence 2: NP_001162871.1
• Gene: ine / 33659
• FlyBaseID: FBgn0011603
• Length: 943
• Species: Drosophila melanogaster
• Alignment Length: 561
• Identity: 219/561 - (39%)
• Similarity: 343/561 - (61%)
• Gaps: 26/561 - (4%)

Mouse    79 RETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYH 143
            ::.|..||.|:|:.|||:|.|||:|||||:||::|||.||:||.|:.....|||.:|||::|||.
  Fly   337 QQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPYCIILFICSIPLLFMELSVGQYT 401

Mouse   144 RNGCISIWKKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSFTDQLPWTSCKNSWNTGN 208
            ..|.|....::||:|||.|.|..:::|.:::||:.||.:::||..:||..::||..|.|.|||.:
  Fly   402 GRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYYFFTSFKTEMPWIDCNNRWNTPD 466

Mouse   209 C-------TNYFAQDNITWTLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLALCIMLIFTII 266
            |       .|..|.|.      |.:|:|||:...||||  |.||:..|.:.|:|..|::..:.::
  Fly   467 CWVPQRKGINASAPDT------SRTPSEEFFENKVLQI--SGGLEYPGMMRWELFACLICAWLMV 523

Mouse   267 YFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAA 331
            ||:.||.:|:|.||.:.|||||::::.:|:||..||.||..|:.|:.:|.|.:|....||::||:
  Fly   524 YFATWKSIKSSAKVRYFTATFPFVLIIILMVRAVTLDGAAEGLRFFFRPKWSELKNANVWINAAS 588

Mouse   332 QIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSE 396
            |.|.|||..||.:::||||||:|||..:|.:..|.||.:||.:.|...|:.||.:|..:|.:|.:
  Fly   589 QNFNSLGITFGSMISFASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVRD 653

Mouse   397 VAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKR 461
            |..| ||.::|:.|.:|:|.||.:..:|::||.||:.|||:|.||.:|.|:|::.|.||. |.||
  Fly   654 VIGD-GPGMIFVVYPQAMAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPR-WIKR 716

Mouse   462 ----REWFVLIV-VITCILGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVVVSWFYGITQF 521
                .|..||.| ||:|:.| :..:..||.|...|::.||....::.:|..:.:.::||||..:.
  Fly   717 HLGYHEIVVLFVCVISCLFG-MPNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAIAWFYGTGRL 780

Mouse   522 CSDVKEMLGFSPGWFWRICWVAISP--LFLLFIICSFLMSPPQLRLFQYNYPHWSIILGYCIGTS 584
            ..:||:|.|.:|.::.|.||:.:.|  ||.::::.......|.....:|.||.|:..:|:...:.
  Fly   781 SKNVKQMTGKAPSFYLRSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASF 845

Mouse   585 SVICIPIYIIYRLISTPG-TLKERIIKSITPETPTEIPCGD 624
            |:||||.|.:...:.:.| |..|||..::.|.......||:
  Fly   846 SLICIPGYAVINFLRSSGDTFWERIRNTLRPNIYECKICGE 886

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Slc6a4	NP_034614.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63
		5HT_transport_N	24..64	CDD:281488
		SLC6sbd_SERT	79..615	CDD:271399	216/550 (39%)
		Interaction with RAB4A. /evidence=ECO:0000250	616..624		1/7 (14%)
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	216/549 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820