Protein Alignment Htr3a and nAChRbeta1

DIOPT Version :10

• Sequence 1: NP_038589.2
• Gene: Htr3a / 15561
• MGIID: 96282
• Length: 489
• Species: Mus musculus
• Sequence 2: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Alignment Length: 531
• Identity: 138/531 - (25%)
• Similarity: 239/531 - (45%)
• Gaps: 94/531 - (17%)

Mouse     3 LCIPQVLLALFLSMLTAPGEGSRRRATQARDTTQPALLRLSDHLLANYKKGVRPVRDWRKPTTVS 67
            ||...||:|..|...:...|                  ||...|...|.|.:|||::..:...|.
  Fly    10 LCSILVLVAFSLVSASEDEE------------------RLVRDLFRGYNKLIRPVQNMTQKVGVR 56

Mouse    68 IDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVD 132
            ..:....::||:||||::.:.:|.|..|.|..|||...|:..:..|.:|.|.:|.|||::  |.:
  Fly    57 FGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVL--FNN 119

Mouse   133 VGKSPNIPY---VYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITL 194
            ...:..:.|   |.::..|||....|....::|::|:..||||.|.|.:.|.||......:::.|
  Fly   120 ADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLAL 184

Mouse   195 WRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISN-SYAEMKFYVIIRRRPLFYAVSLLLPS 258
            :.:...|  |.|.:...|.|:::||......:..|.:: :..::.||:||||:.|||.|:|:||:
  Fly   185 YNNKNFV--DLSDYWKSGTWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPT 247

Mouse   259 IFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVI 323
            :.:..:.::.|.||.::||:|:..|::||...|||::||..||.|::..|||..|.:....:..:
  Fly   248 VLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTV 312

Mouse   324 SLAETIFIVRLVHKQDLQRPVPDWLRHLVL--------------DRIAWILCLGEQPMAHRPPAT 374
            |:..|:.|:....:......:|.::|.:.|              .|:.|::.:....|...|..:
  Fly   313 SILVTVIIINWNFRGPRTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPS 377

Mouse   375 FQANKTDDCSGSDLLPA-MGNHCSHVGGPQ---------DLE----KTPR--GRGSPL------- 416
            :         ||   || :..|.|.:||.|         ||.    |..|  ..|..|
  Fly   378 Y---------GS---PAELPKHISAIGGKQSKMEVMELSDLHHPNCKINRKVNSGGELGLGDGCR 430

Mouse   417 ------------PPPREASLAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYL 469
                        |...:|:.||..:.:.|.:...:::.|:       ||..|..|:|||...|:.
  Fly   431 RESESSDSILLSPEASKATEAVEFIAEHLRNEDLYIQTRE-------DWKYVAMVIDRLQLYIFF 488

Mouse   470 LAVLAYSITLV 480
            :...|.::.::
  Fly   489 IVTTAGTVGIL 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Htr3a	NP_038589.2	LIC	5..483	CDD:273305	136/529 (26%)
		HA-stretch, determines single-channel conductance in 5-HT3 receptors. /evidence=ECO:0000250|UniProtKB:P46098	425..461		8/35 (23%)
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	138/531 (26%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	64/230 (28%)
		Cys-loop	152..166	CDD:349833	7/13 (54%)