DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp90aa1 and Gp93

DIOPT Version :9

Sequence 1:	NP_034610.1	Gene:	Hsp90aa1 / 15519	MGIID:	96250	Length:	733	Species:	Mus musculus
Sequence 2:	NP_651601.1	Gene:	Gp93 / 43354	FlyBaseID:	FBgn0039562	Length:	787	Species:	Drosophila melanogaster

Alignment Length:	735	Identity:	336/735 - (45%)
Similarity:	479/735 - (65%)	Gaps:	40/735 - (5%)

- Green bases have known domain annotations that are detailed below.

Mouse    15 EEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHIN 79
            |:.:.|.||.|:.::|.||||:.|.||||||||||||:|||:||||..:|::..:|::..||||.
  Fly    70 EKAKKFTFQTEVNRMMKLIINSLYRNKEIFLRELISNASDAIDKIRLLALSNSKELETNPELHIR 134

Mouse    80 LIPSKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQ-----AGADIS-MIGQFGVGF 138
            :...|:::.|.|:|:|||||..||||||||||||||..|:..:|     .|.|:: |||||||||
  Fly   135 IKADKENKALHIMDSGIGMTHQDLINNLGTIAKSGTADFLAKMQDPSKSEGLDMNDMIGQFGVGF 199

Mouse   139 YSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTD-TGEPMGRGTKVILHLKEDQTEYLEERR 202
            |||:|||::|.|.||||||:||.|||.| .||::..| .|:.:.||:.:.|:|||:..::|||..
  Fly   200 YSAFLVADRVVVTTKHNDDKQYIWESDA-NSFSITEDPRGDTLKRGSVISLYLKEEAQDFLEEDT 263

Mouse   203 IKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEEKEEEKEKEEKESDDKPEIEDVGSDEEE 267
            ::|:::|:||||.:||.::..|..::||          ..||:.|.||..||   :||  .|.:.
  Fly   264 VRELIRKYSQFINFPIRMWSSKTVEEEV----------PVEEEAKPEKSEDD---VED--EDAKV 313

Mouse   268 EEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEEHLAVKHFSV 332
            ||.:| :|.|.||:.:...|...:|.:||||||.|.::|.:||..||||||.|..|.|...||..
  Fly   314 EEAED-EKPKTKKVSKTTWDWTLINDSKPIWTRKPAEVTEDEYTSFYKSLTKDSSEPLTQTHFIA 377

Mouse   333 EGQLEFRALLFVPRRAPFDLFENR--KKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDL 395
            ||::.|::||:||:..|.:.| ||  .|.:|||||||||||.|...:::|.||:||||||||:||
  Fly   378 EGEVTFKSLLYVPKVQPSESF-NRYGTKSDNIKLYVRRVFITDEFNDMMPNYLSFIRGVVDSDDL 441

Mouse   396 PLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKL 460
            |||:|||.|||.|::|||:|.||:|.|::..::  |||.|:||:::||.|||||:.||..||.:|
  Fly   442 PLNVSRETLQQHKLIKVIKKKLVRKVLDMLKKI--DKEAYEKFWKEFSTNIKLGVMEDPSNRSRL 504

Mouse   461 SELLRYYTSASGDEMVSLKDYCTRMKENQKHIYFITGETKDQVANSAFVERLRKHGLEVIYMIEP 525
            ::|||:.|| :|..:.||.:|..|||..|:|||:|.|..:.:|..|.|||||...|.||:|::|.
  Fly   505 AKLLRFQTS-NGKGVTSLAEYKERMKAKQEHIYYIAGANRAEVEKSPFVERLLSKGYEVLYLVEA 568

Mouse   526 IDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDI-LEKKVEKVVV 589
            :||||:..|.||:||...:|.|||.:|.|.|:.||..|..|:.||.|.|.:.|: |:.::.|..|
  Fly   569 VDEYCISALPEFDGKKFQNVAKEGFQLNESEKSKKNFESLKSTFEPLVKWLNDVALKDQISKAQV 633

Mouse   590 SNRLVTSPCCIVTSTYGWTANMERIMKAQALR---DNSTMGYMAAKKHLEINPDHSIIETLRQKA 651
            |.||..|||.:|...:|||.||||:..:.|.:   |.....|:..||.|||||.|.::..|.::.
  Fly   634 SERLSNSPCALVAGVFGWTGNMERLAMSNAHQKSDDPQRTYYLNQKKTLEINPRHPLMRELLRRV 698

Mouse   652 EADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPT------VDDTS 710
            |||:.|.:.||:.::::.||.|.||:.|::....|:.|.:|::..||:.:|:..      .||..
  Fly   699 EADEADDTAKDMAVMMFRTATLRSGYMLQETSQFADSIEQMMRQTLGVSQDEQVEFDEEEEDDAE 763

Mouse   711 AAVTEEMPPLEGDDDTSRME 730
            ...|........||:....:
  Fly   764 ETATGSQESGNADDEEEEQQ 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp90aa1	NP_034610.1	Interaction with NR3C1. /evidence=ECO:0000269\|PubMed:27686098	9..236		116/227 (51%)
		PTZ00272	18..733	CDD:240341	335/732 (46%)
		HATPase_c	40..191	CDD:214643	88/157 (56%)
		HSP90	196..723	CDD:278607	232/538 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	225..279		17/53 (32%)
		Interaction with NR3C1. /evidence=ECO:0000269\|PubMed:27686098	272..617		173/347 (50%)
		Interaction with FLCN and FNIP1. /evidence=ECO:0000250\|UniProtKB:P07900	285..733		203/458 (44%)
		Interaction with FNIP2 and TSC1. /evidence=ECO:0000250\|UniProtKB:P07900	285..621		169/338 (50%)
		Interaction with NR1D1. /evidence=ECO:0000269\|PubMed:27686098	629..732		32/108 (30%)
		Required for homodimerization. /evidence=ECO:0000250\|UniProtKB:P07900	683..733		11/54 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	701..733		6/36 (17%)
		TPR repeat-binding. /evidence=ECO:0000250\|UniProtKB:P07900	724..733		1/7 (14%)
		Essential for interaction with SMYD3, TSC1 and STIP1/HOP. /evidence=ECO:0000250\|UniProtKB:P07900	729..733		0/2 (0%)
		Essential for interaction with SGTA and TTC1. /evidence=ECO:0000250\|UniProtKB:P07900	730..733		0/1 (0%)
Gp93	NP_651601.1	PRK05218	74..745	CDD:235366	327/691 (47%)
		HATPase_c	97..216	CDD:238030	69/118 (58%)
		HSP90	257..748	CDD:278607	228/510 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0326
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D174605at33208
OrthoFinder	1	1.000	-	-		FOG0000295
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100204
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X234
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.720