DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP3A7 and Cyp4e1

DIOPT Version :9

Sequence 1:	NP_000756.3	Gene:	CYP3A7 / 1551	HGNCID:	2640	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_524771.1	Gene:	Cyp4e1 / 44632	FlyBaseID:	FBgn0015034	Length:	531	Species:	Drosophila melanogaster

Alignment Length:	528	Identity:	133/528 - (25%)
Similarity:	246/528 - (46%)	Gaps:	75/528 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    12 WLLLAVSLIL-LYLYGTRTHGLFKKLGI----PGPTPLPFLGNA----------LSFRKGYWTFD 61
            |::|...|.| |:|......||.::..:    .||:.||.:|||          |:...|:|
  Fly     2 WIVLCAFLALPLFLVTYFELGLLRRKRMLNKFQGPSMLPLVGNAHQMGNTPTEILNRFFGWW--- 63

Human    62 MECYKKYRKVW-GIYDCQQPMLAITDPDMIKTVLVKECY----SVFTNRRPFGPVGFMKNAISIA 121
            .|..|...:.| |.|.    .:.:|:|..::.:|..:..    .|:....|:..:|.:.:..|
  Fly    64 HEYGKDNFRYWIGYYS----NIMVTNPKYMEFILSSQTLISKSDVYDLTHPWLGLGLLTSTGS-- 122

Human   122 EDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITS 186
               :|.:.|.:::|.|....|::...::.:.....:..|::.|:.|.....:......::|||..
  Fly   123 ---KWHKHRKMITPAFHFNILQDFHEVMNENSTKFIDQLKKVADGGNIFDFQEEAHYLTLDVICD 184

Human   187 TSFGVSIDSLNNPQDPFVENTKKL---LRFNPLDPFVLSIKVFPFLTPILEALNITV-----FPR 243
            |:.||||:::.|.....|:..|.:   ::.....|:..:..:|.| .|.....:.|:     |..
  Fly   185 TAMGVSINAMENRSSSVVQAFKDITYTIKMRAFSPWKRNKYLFHF-APEYPEYSKTLKTLQDFTN 248

Human   244 KVISFLTKSVKQIKEG-----RLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFI 303
            ::|:   |.::..|.|     :..|..:.::.||..::.|:     ...:.|:..||..:...|:
  Fly   249 EIIA---KRIEVRKSGLEVGIKADEFSRKKMAFLDTLLSSK-----VDGRPLTSQELYEEVSTFM 305

Human   304 FAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKA---PPTYDTVLQLEYLDMVVNETLR 365
            |.|::||:|.:.|.:|.|:.|||.|:|:..|...|:....   ..|:..:..:::||:.:.|..|
  Fly   306 FEGHDTTTSGVGFAVYLLSRHPDEQEKLFNEQCDVMGASGLGRDATFQEISTMKHLDLFIKEAQR 370

Human   366 LFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPY 430
            |:|....:.|..:||..|:|..:|||..:.:...:|.::.:.:.:|.||.||||   :::...|:
  Fly   371 LYPSVPFIGRFTEKDYVIDGDIVPKGTTLNLGLLMLGYNDRVFKDPHKFQPERF---DREKPGPF 432

Human   431 IYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPC------KETQIPLKLRFGGLLLTEKPI 489
            .|.||.:|||||||.:|||:.:|..:.::::||...|.      |:..|...|   ||...||
  Fly   433 EYVPFSAGPRNCIGQKFALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTL---GLQPAEK-- 492

Human   490 VLKAESRD 497
                :|||
  Fly   493 ----KSRD 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A7	NP_000756.3	p450	39..492	CDD:365848	122/489 (25%)
Cyp4e1	NP_524771.1	p450	34..469	CDD:278495	114/458 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810