DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CYP3A7 and Cyp6d4

DIOPT Version :9

Sequence 1:	NP_000756.3	Gene:	CYP3A7 / 1551	HGNCID:	2640	Length:	503	Species:	Homo sapiens
Sequence 2:	NP_651082.1	Gene:	Cyp6d4 / 42682	FlyBaseID:	FBgn0039006	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	517	Identity:	174/517 - (33%)
Similarity:	275/517 - (53%)	Gaps:	63/517 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    13 LLLAVSLI-LLYLYGTRTHGLFKKLGIP--GPTPLPF--LGNALSFRK--GYWTFDMECYKKYRK 70
            :||||:|: |.:.|..|.:..:::.|.|  ..:.:||  |.:.....|  |...:|:....|.|
  Fly     5 ILLAVTLLTLAWFYLKRHYEYWERRGFPFEKHSGIPFGCLDSVWRQEKSMGLAIYDVYVKSKER- 68

Human    71 VWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPF-----GPVGFMKNAISIAEDEEWKRIR 130
            |.|||...:|.:.|.|.|:.:.||.:: ::.|.:|..:     .|:.  .|..|: ..:.|:.:|
  Fly    69 VLGIYLLFRPAVLIRDADLARRVLAQD-FASFHDRGVYVDEERDPLS--ANIFSL-RGQSWRSMR 129

Human   131 SLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRRE-AETG-KPVTLKHVFGAYSMDVITSTSFGVSI 193
            .:|||.|||||||.|.......||.:|.:|::| .|.| |.|.:|.|...|::|:|.||.||:.:
  Fly   130 HMLSPCFTSGKLKSMFSTSEDIGDKMVAHLQKELPEEGFKEVDIKKVMQNYAIDIIASTIFGLDV 194

Human   194 DSLNNPQDPFVENTKKLL-------RFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLTK 251
            :|..||.:.|    :||:       |||.:  |.:.|.:.|.:...|..:.   |...|...:.:
  Fly   195 NSFENPDNKF----RKLVSLARANNRFNAM--FGMMIFLVPSIAQFLFRIG---FKNPVGLAMLQ 250

Human   252 SVKQIKEGRLKETQKH---RVDFLQLMIDSQNS--------------KDSETH-KALSDLELMAQ 298
            .||:..|.|    :||   |.|.|||:|..:|:              |..:.| |.:|...:.||
  Fly   251 IVKETVEYR----EKHGIVRKDLLQLLIQLRNTGKIDENDEKSFSIQKTPDGHIKTISLEAITAQ 311

Human   299 SIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEID-TVLPNKAPPTYDTVLQLEYLDMVVNE 362
            :.||..||.|||.|..:|.|||||.:|::.:::|.|:| |:..|....|||::.::|:||:.|.|
  Fly   312 AFIFYIAGQETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKNDGKITYDSLNKMEFLDLCVQE 376

Human   363 TLRLFPVAMRLERVCKKDVEI--NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKD 425
            |:|.:|....|.|.|.:|..:  ....||||..|:|..|.:|||.:|:.:||.:.|||||::::
  Fly   377 TIRKYPGLPILNRECTQDYTVPDTNHVIPKGTPVVISLYGIHHDAEYFPDPETYDPERFSEESR- 440

Human   426 NIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEK 487
            |.:|..:.|||.|||.||..|...:|.|||::::||||:.:....::|  :....|:.|..|
  Fly   441 NYNPTAFMPFGEGPRICIAQRMGRINSKLAIIKILQNFNVEVMSRSEI--EFENSGIALIPK 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A7	NP_000756.3	p450	39..492	CDD:365848	165/490 (34%)
Cyp6d4	NP_651082.1	p450	58..500	CDD:278495	158/462 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920