Protein Alignment CYP3A7 and Cyp6d2

DIOPT Version :10

• Sequence 1: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_611698.1
• Gene: Cyp6d2 / 37594
• FlyBaseID: FBgn0034756
• Length: 512
• Species: Drosophila melanogaster
• Alignment Length: 545
• Identity: 155/545 - (28%)
• Similarity: 263/545 - (48%)
• Gaps: 95/545 - (17%)

Human    12 WLLLAVSLI--LLYLYGTRTHGLFKKLGI-PGPTPLPF------------LGNALSFRKGYWTFD 61
            |.:|...||  |||.|..|.:..:::||: ..|..:||            ||.||:
  Fly     2 WTILLTILIAGLLYRYVKRHYTHWQRLGVDEEPAKIPFGVMDTVMKQERSLGMALA--------- 57

Human    62 MECYKKYR-KVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIAEDEE 125
             :.|.::. |:.|||...:..:.|.|..:.:.::..:..|            |....:.:.||::
  Fly    58 -DIYARHEGKIVGIYMLNKRSILIRDAQLARQIMTSDFAS------------FHDRGVYVDEDKD 109

Human   126 -------------WKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFG 177
                         |:.:|..|:|:|:|||:|.|...|...||.||::|....:....|.:|.|..
  Fly   110 PLSANLFNLRGASWRNLRQKLTPSFSSGKIKGMFGTIDDVGDKLVQHLEGALDQSDEVEIKDVMT 174

Human   178 AYSMDVITSTSFGVSIDSLNNPQDPFVE---NTKK----LLRFNPLDPFVLSIKVFPFLTPILEA 235
            .|::|:|.|..||:.|||..||::.|.|   :|.:    ||:.:.:..|:        ..||.:.
  Fly   175 TYAVDIIGSVIFGLEIDSFRNPKNEFREISSSTSRDESLLLKIHNMSMFI--------CPPIAKL 231

Human   236 LNITVFPRKVISFLTKSVKQIKEGRLKETQKHRV---DFLQLMIDSQNSK----------DSETH 287
            :|...:..::::.|...:|:..|.|    ::|.|   |.|||:|..:|:.          |.||.
  Fly   232 MNRLGYESRILTSLRDMMKRTIEFR----EEHNVVRKDMLQLLIRLRNTGKIGEDDDQVWDMETA 292

Human   288 ----KALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVL--PNKAPP- 345
                |::|..::.||:.:|..||.|:|::..:|.:|||:.:|::.::.|:|:|.||  .|..|.
  Fly   293 QEQLKSMSIEKIAAQAFLFYVAGSESTAAASAFTLYELSMYPELLKEAQEEVDAVLMKHNLKPKD 357

Human   346 --TYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGM--FIPKGVVVMIPSYVLHHDPK 406
              ||:.|..|::||:.:.||:|.:|....|.|.|.:|..:.|.  .|.||..::|..:.:..||.
  Fly   358 RFTYEAVQDLKFLDICIMETIRKYPGLPFLNRECTEDYPVPGTNHIIAKGTPILISLFGMQRDPV 422

Human   407 YWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKET 471
            |:..|..:.|.||...|. |.|...|.|||.|||:||.:|...||.|:|:.::|.||........
  Fly   423 YFPNPNGYDPHRFDSNNM-NYDQAAYMPFGEGPRHCIALRMGKVNSKVAVAKILANFDLVQSPRK 486

Human   472 QIPLKLRFGGLLLTEKPIVLKAESR 496
            ::..:.....:|:|::|:.|:...|
  Fly   487 EVEFRFDAAPVLVTKEPLKLRLTKR 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A7	NP_000756.3	CYP3A	67..492	CDD:410743	134/469 (29%)
Cyp6d2	NP_611698.1	CYP6-like	63..505	CDD:410679	134/466 (29%)