Protein Alignment CYP3A7 and Cyp6d2

DIOPT Version :9

• Sequence 1: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_611698.1
• Gene: Cyp6d2 / 37594
• FlyBaseID: FBgn0034756
• Length: 512
• Species: Drosophila melanogaster
• Alignment Length: 545
• Identity: 155/545 - (28%)
• Similarity: 263/545 - (48%)
• Gaps: 95/545 - (17%)

Human    12 WLLLAVSLI--LLYLYGTRTHGLFKKLGI-PGPTPLPF------------LGNALSFRKGYWTFD 61
            |.:|...||  |||.|..|.:..:::||: ..|..:||            ||.||:
  Fly     2 WTILLTILIAGLLYRYVKRHYTHWQRLGVDEEPAKIPFGVMDTVMKQERSLGMALA--------- 57

Human    62 MECYKKYR-KVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIAEDEE 125
             :.|.::. |:.|||...:..:.|.|..:.:.::..:..|            |....:.:.||::
  Fly    58 -DIYARHEGKIVGIYMLNKRSILIRDAQLARQIMTSDFAS------------FHDRGVYVDEDKD 109

Human   126 -------------WKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFG 177
                         |:.:|..|:|:|:|||:|.|...|...||.||::|....:....|.:|.|..
  Fly   110 PLSANLFNLRGASWRNLRQKLTPSFSSGKIKGMFGTIDDVGDKLVQHLEGALDQSDEVEIKDVMT 174

Human   178 AYSMDVITSTSFGVSIDSLNNPQDPFVE---NTKK----LLRFNPLDPFVLSIKVFPFLTPILEA 235
            .|::|:|.|..||:.|||..||::.|.|   :|.:    ||:.:.:..|:        ..||.:.
  Fly   175 TYAVDIIGSVIFGLEIDSFRNPKNEFREISSSTSRDESLLLKIHNMSMFI--------CPPIAKL 231

Human   236 LNITVFPRKVISFLTKSVKQIKEGRLKETQKHRV---DFLQLMIDSQNSK----------DSETH 287
            :|...:..::::.|...:|:..|.|    ::|.|   |.|||:|..:|:.          |.||.
  Fly   232 MNRLGYESRILTSLRDMMKRTIEFR----EEHNVVRKDMLQLLIRLRNTGKIGEDDDQVWDMETA 292

Human   288 ----KALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVL--PNKAPP- 345
                |::|..::.||:.:|..||.|:|::..:|.:|||:.:|::.::.|:|:|.||  .|..|.
  Fly   293 QEQLKSMSIEKIAAQAFLFYVAGSESTAAASAFTLYELSMYPELLKEAQEEVDAVLMKHNLKPKD 357

Human   346 --TYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGM--FIPKGVVVMIPSYVLHHDPK 406
              ||:.|..|::||:.:.||:|.:|....|.|.|.:|..:.|.  .|.||..::|..:.:..||.
  Fly   358 RFTYEAVQDLKFLDICIMETIRKYPGLPFLNRECTEDYPVPGTNHIIAKGTPILISLFGMQRDPV 422

Human   407 YWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKET 471
            |:..|..:.|.||...|. |.|...|.|||.|||:||.:|...||.|:|:.::|.||........
  Fly   423 YFPNPNGYDPHRFDSNNM-NYDQAAYMPFGEGPRHCIALRMGKVNSKVAVAKILANFDLVQSPRK 486

Human   472 QIPLKLRFGGLLLTEKPIVLKAESR 496
            ::..:.....:|:|::|:.|:...|
  Fly   487 EVEFRFDAAPVLVTKEPLKLRLTKR 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A7	NP_000756.3	p450	39..492	CDD:365848	142/509 (28%)
Cyp6d2	NP_611698.1	p450	65..506	CDD:278495	134/465 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920