Protein Alignment CYP3A7 and Cyp317a1

DIOPT Version :9

• Sequence 1: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Sequence 2: NP_001286435.1
• Gene: Cyp317a1 / 36667
• FlyBaseID: FBgn0033982
• Length: 518
• Species: Drosophila melanogaster
• Alignment Length: 544
• Identity: 136/544 - (25%)
• Similarity: 250/544 - (45%)
• Gaps: 82/544 - (15%)

Human    12 WL------LLAVSLILLYLYGTR-THGLFKKLGIPGPTPLPFLGNALSFRKGYW---------TF 60
            |:      ||.:.|::|.:...| ....::.|.||...|           |..|         |.
  Fly     2 WIIFLIIGLLVLGLLVLLIIAARYQRDYWRYLDIPHERP-----------KKLWPIIRQIMTQTL 55

Human    61 DMEC---------YKKYR---KVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGF 113
            ..|.         |||::   ...|.|...||...|.|.::|:.:::|:.:: |.:|      |.
  Fly    56 STEAMKAEHYSAIYKKFKGSGPFCGFYALLQPRALILDRELIRQIMIKDFWN-FNDR------GL 113

Human   114 MKNAIS--IAED------EEWKRIRSLLSPTFTSGKLKEMVPIIAQYGD--VLVRNLRREAETGK 168
            ..|..|  ::.|      |.||.:|..|.|:....::..:...:.:..:  :|..|....::...
  Fly   114 YCNQKSDPLSGDLYALRGESWKEMRQKLDPSLEGDRMSLLYDCLYEEAEQLLLTVNSTLMSQPHS 178

Human   169 PVTLKHVFGAYSMDVITSTSFGVSIDSLNN-PQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPI 232
            .|.::.:...|.:..:....||::.:.... |.:.|.:.|:..|..:. ..:::::.:..| ...
  Fly   179 TVHIQKIMRRYVLSSLAKCVFGLNAEQRKTYPLEDFEQMTELALNSHK-HGYLMNLMMIRF-PNF 241

Human   233 LEALNITVFPRKVISFLTKSVKQIKEGRLKETQ-KHRVDFLQLMID--------SQNSKDSETHK 288
            ...|.:...|::...:..|.:..|.|.|  ||. |.:.|:|||:||        .|...|.|...
  Fly   242 CRMLRMRRTPKQAEEYFIKLLTSIVEQR--ETSGKPQKDYLQLLIDVKALEFITHQYEADKELGA 304

Human   289 ALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLP-NKAPPTYDTVLQ 352
            .|.: ||.|.:::|:.||||.|::.||:::||||.||::|.:|::|:...:. :....|::.:..
  Fly   305 HLQN-ELAAHAVVFLKAGYEQTANTLSYVLYELALHPELQVRVREEVKKAIERHDGHITHEGIKS 368

Human   353 LEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVV-----MIPSYVLHHDPKYWTEPE 412
            |.::..|:|||||:.|:...:.|....|..:...  ||.::|     :||::.:||||..:.:||
  Fly   369 LSFMGQVINETLRMHPITPYILRRTLNDYAVPDH--PKYILVKELFLIIPTHAIHHDPDIYPDPE 431

Human   413 KFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKL 477
            :|.|:|:|.......:...:..||.|.|:|||::||.:.::|||..:|..:.|.  ..|:.||..
  Fly   432 EFKPDRWSGPRDSLQEQGTWFGFGVGARSCIGIQFAQLQLRLALALLLSEYEFS--LNTRKPLIN 494

Human   478 RFGGLLLTEKPI-VLKAESRDETV 500
            ...|:.||..|: |::..:.:..|
  Fly   495 LEDGIALTLMPLGVIEPGNEERAV 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CYP3A7	NP_000756.3	p450	39..492	CDD:365848	127/500 (25%)
Cyp317a1	NP_001286435.1	p450	39..466	CDD:299894	111/451 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920